Biotechnology Letters

, Volume 27, Issue 21, pp 1641–1648 | Cite as

Nisin Biosynthesis and its Properties

  • Chan-Ick Cheigh
  • Yu-Ryang PyunEmail author


The antimicrobial peptide, nisin, produced by several strains of Lactococcus lactis, which belongs to the Class I bacteriocins called lantibiotics, is a small (3.4 kDa), 34-amino acid, cationic, hydrophobic peptide and has the five characteristic (β-methyl)lanthionine rings formed by significant post-translational modification. A cluster of 11 genes has been involved in the biosynthesis of nisin and are proposed to be transcriptionally arranged as nisA(Z)BTCIP, nisRK, and nisFEG. The biosynthesis of nisin is regulated in a growth-phase-dependent manner including nisin-mediated induction which occurs via NisRK two-component regulatory system. This review outlines some of the more recent developments in the properties, regulation and applications of nisin biosynthesis.

Key words

nisin nisin biosynthesis nisin-mediated induction regulation two-component regulatory system 


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Copyright information

© Springer 2005

Authors and Affiliations

  1. 1.Department of BiotechnologyYonsei UniversitySeoulKorea
  2. 2.R&D Division, Biovan Co. Ltd.Yonsei UniversitySeoulKorea

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