Abstract
Novel mutual pro-drugs in which 2′,3′-dideoxyinosine anti-HIV (human immunodeficiency virus) drug and 3-octadecyloxy-propane-1,2-diol anti-inflammatory drug were attached to the same molecule via different biodegradable linkages, were synthesized through two-step enzymatic transesterification by a commercial lipase in acetone.
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Revisions requested 8 October 2004; Revisions received 27 November 2004
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Sun, XF., Wu, Q., Wang, N. et al. Novel mutual pro-drugs of 2′,3′-dideoxyinosine with 3-octadecyloxy-propane-1,2-diol by straightforward enzymatic regioselective synthesis in acetone . Biotechnol Lett 27, 113–117 (2005). https://doi.org/10.1007/s10529-004-7335-1
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DOI: https://doi.org/10.1007/s10529-004-7335-1