Abstract
A porous, biodegradable, natural chitin/chitosan nerve conduit was constructed. Scanning electron microscopy confirmed that it was homogeneous and highly porous. FT-IR spectra showed that there were no residues arising from the preparation process in the conduit. Addition of chitin to the chitosan solution increased the mechanical strength and maximum tensile strength from 7.2 to 9.6 MPa. Preliminary animal tests indicated that porous chitin/chitosan conduits did not swell in vivo and were compatible with surrounding tissue.
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References
P Aebischer V Guenard RF Valentini (1990) ArticleTitleThe morphology of regenerating peripheral nerves is modulated by the surface microgeometry of polymeric guidance channels Brain Res. 531 211–218 Occurrence Handle1:STN:280:By6C2crmslM%3D
H Fansa W Schneider G Wolf (2002) ArticleTitleHost responses after acellular muscle basal lamina allografting used as a matrix for tissue engineered nerve grafts Transplantation 74 381–387
XS Gu PY Zhang XD Wang F Ding LP Peng HB Cheng (2003) ArticleTitleDog sciatic nerve gap repaired by artificial tissue nerve graft Prog. Nat. Sci. 13 578–583
S Itoh K Takakuda S Kawabata (2002) ArticleTitleEvaluation of cross-linking procedures of collagen tubes used in peripheral nerve repair Biomaterials 23 4475–4481 Occurrence Handle1:CAS:528:DC%2BD38XmsVeru7s%3D
RD Keeley KD Nguyen MJ Stephanides (1991) ArticleTitleThe artificial nerve graft: a comparison of blended elastomer-hydrogel with polyglycolic acid conduits J. Reconstr. Microsurg. 7 93–100 Occurrence Handle10.1055/s-2007-1006766 Occurrence Handle1:STN:280:By6B28bisFA%3D
MF Meek JH Coert (2002) ArticleTitleClinical use of nerve conduits in peripheral nerve repair: review of the literature J. Reconstr. Microsurg. 18 97–109 Occurrence Handle1:STN:280:DC%2BD38%2FpsVaktw%3D%3D
YJ Seol JY Lee YJ Park YM Lee Y Ku IC Rhyu SJ Lee SB Han CP Chung (2004) ArticleTitleChitosan sponges as tissue engineering scaffolds for bone formation Biotechnol. Lett. 26 1037–1041 Occurrence Handle1:CAS:528:DC%2BD2cXltFWmsr4%3D
SS Simone MCM Sonia BG Rosangela (2003) ArticleTitleSynthesis and characterization of polyuerethane-g-chitosan Eur. Polymer J. 39 1515–1519
C Sundback T Hadlock M Cheney J Vacanti (2003) ArticleTitleManufacture of porous polymer nerve conduits by a novel low-pressure injection moulding process Biomaterials 24 819–830 Occurrence Handle1:CAS:528:DC%2BD38XpsV2qtr8%3D
XH Wang DP Li WJ Wang QL Feng (2003) ArticleTitleCrosslinked collagen/chitosan matrix for artificial livers Biomaterials 24 3213–3220 Occurrence Handle1:CAS:528:DC%2BD3sXjvVanurc%3D
I Yamaguchi S Itoh M Suzuki A Osaka J Tanaka (2003) ArticleTitleThe chitosan prepared from crab tendons: II. The chitosan/apatite composites and their application to nerve regeneration Biomaterials 24 3285–3292 Occurrence Handle1:CAS:528:DC%2BD3sXjvVanu7k%3D
YM Yang JW Wang RX Tan (2004) ArticleTitleImmobilization of glucose oxidase on chitosan-SiO 2 gel Enzyme Microb. Technol. 34 126–131 Occurrence Handle1:CAS:528:DC%2BD2cXovFOq
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Yang, Y., Gu, X., Tan, R. et al. Fabrication and properties of a porous chitin/chitosan conduit for nerve regeneration. Biotechnol Lett 26, 1793–1797 (2004). https://doi.org/10.1007/s10529-004-4611-z
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DOI: https://doi.org/10.1007/s10529-004-4611-z