Abstract
The renin–angiotensin–aldosterone system has an indispensable function in the uteroplacental circulation, placental growth, and blood pressure optimization. The angiotensin I converting enzyme (ACE) gene is a critical integrator for electrolyte balance, and water retention, along with inhibiting preeclampsia. The main goal of this pertaining study is to assess the contribution of ACE*(Ins/Del) variant with the susceptibility for preeclampsia with focus on the severity of the disease among gestational hypertensive women. This retrospective study included 225 participants [125 PE gestational women, and 100 normotensive healthy controls] matching with age, and geographical region. PE women classified into 82 early-onset PE women, accompanied with 43 late-onset PE women. Additionally, PE women categorized into 59 mild PE women, together with 66 severe PE women. The genotyping and characterization of ACE*(Ins/Del) variant were applied using the PCR technique. Our findings indicated higher frequency of the ACE*(Del/Del) genotype and ACE*(D allele) with elevated risk of preeclampsia compared to normotensive controls under recessive (OR = 2.09, and p-value = 0.007), and allelic (OR = 1.75, and p-value = 0.012) models. In addition, testing logistic regression revealed that the levels of endothelin-1 and malondialdehyde exposed significant difference for the ACE*(Del/Del) genotype among early-onset and late-onset PE women (p-value = 0.024, and 0.23, respectively). Furthermore, carriers of the ACE*(Del/Del) genotype observed statistically significant with lower sodium concentrations among severe PE women (p-value = 0.034). The ACE*(Del/Del) genotype and ACE*(D allele) were associated with increased risk preeclampsia among gestational women. Furthermore, early-onset PE and late-onset PE were correlated with endothelin-1 and malondialdehyde concentrations among Egyptian women.
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Data Availability
The dataset used in the construction of this present study will be accessible from the corresponding author upon reasonable request.
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EFEA: conceptualization, validation, investigation, methodology, writing—review & editing. RGAE: data curation, formal analysis, methodology, validation, visualization, writing—review & editing. TME: formal analysis, methodology, writing original draft, data curation. SAMA: methodology, formal analysis, data curation. EIAS: methodology, investigation, formal analysis. MAE: methodology, formal analysis, visualization. DAH: investigation, methodology, formal analysis, visualization. NSE: methodology, formal analysis, validation. ETS: methodology, formal analysis, validation. AME: methodology, validation. MIE: methodology, formal analysis, visualization, writing—review & editing. RME: conceptualization, methodology, software, formal analysis, data curation, validation, investigation, writing—review & editing. NA: methodology, formal analysis, validation.
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El Azab, E.F., Abd El-kader, R.G., Elhassan, T.M. et al. Association of ACE*(Insertion/Deletion) Variant with the Elevated Risk of Preeclampsia Among Gestational Women. Biochem Genet (2024). https://doi.org/10.1007/s10528-023-10620-5
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DOI: https://doi.org/10.1007/s10528-023-10620-5