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Association of GSTP1 p.Ile105Val (rs1695, c.313A > G) Variant with the Risk of Breast Carcinoma among Egyptian Women

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Abstract

Several reports examined the association of the GSTP1 p.Ile105Val (rs1695, c.313A > G) variant with the elevated risk of multiple cancerous diseases involving breast carcinoma, but with inconclusive findings. The primary purpose of this study is to test the association of this essential variant with the risk of breast carcinoma among Egyptian females. This case–control study was conducted based on 200 participants involving 100 women diagnosed with breast carcinoma and 100 unrelated cancer-free controls from the same district. The genomic DNA for all participants was genotyped utilizing T-ARMS-PCR procedure. The frequencies of the GSTP1 p.Ile105Val (rs1695, c.313A > G) variant indicated a statistically significant with the elevated risk of breast carcinoma under various genetic models, including allelic (OR = 2.48, P-value < 0.001) and dominant (OR = 2.36, P-value = 0.003) models. In conclusion, the GSTP1 p.Ile105Val (rs1695, c.313A > G) variant was considered as an independent risk factor for breast carcinoma among Egyptian women.

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Fig. 1
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source: Ensembl.org, NCBI database, UniProt database, Compartment database, Protter database, X2K Web database, Kaplan‐Meier plotter database, GeneMania, and STRING version 11.0]

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Data Availability

The dataset utilized in the preparation of the present study will be available from the corresponding author on reasonable request.

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Acknowledgements

The authors are very thankful to the staff colleagues of the Oncology Center, Mansoura University, for supporting the selection of the study participants registered in this work.

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MMY contributed to project administration, conceptualization, validation, investigation, and supervision. AME was involved in formal analysis, methodology, validation, visualization, and writing—review and editing. RAE was involved in data curation, methodology, validation, and writing—review and editing. RTM contributed to methodology, formal analysis, and writing original draft. HM contributed to methodology, software development, validation, and formal analysis. AIA was involved in methodology, software development, formal analysis, and writing original draft. RME contributed to conceptualization, methodology, software, formal analysis, data curation, validation, investigation, and writing—review and editing.

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Correspondence to Rami M. Elshazli.

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Informed consent was accomplished from all individual females who participated in this work.

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Youssef, M.M., Elsaid, A.M., El-Saeed, R.A. et al. Association of GSTP1 p.Ile105Val (rs1695, c.313A > G) Variant with the Risk of Breast Carcinoma among Egyptian Women. Biochem Genet 59, 1487–1505 (2021). https://doi.org/10.1007/s10528-021-10070-x

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