Abstract
Several studies have previously assessed the association between interleukin (IL)-10 gene polymorphisms and the risk of asthma, leading to conflicting results. To resolve the incongruent outcomes yielded from different single studies, we conducted the most up-to-date meta-analysis of the IL-10 gene rs1800896, rs1800871, and rs1800872 single-nucleotide polymorphisms (SNPs) and susceptibility to asthma. A systematic literature search performed until April 2020, and the pooled odds ratio (OR) and their corresponding 95% confidence interval (CI) were calculated to determine the association strength. Thirty articles comprising 5678 asthmatic patients and 6079 controls met the inclusion criteria. No significant association was found between rs1800872 SNP and susceptibility to asthma across all genetic models in the overall and subgroup analyses. The rs1800871 SNP had only significant association with a decreased risk of asthma in Europeans (OR 0.66, CI 0.53–0.82, P < 0.001). However, rs1800896 SNP was significantly associated with a decreased risk of asthma by dominant (OR 0.67, CI 0.50–0.90, P < 0.001) and heterozygote (OR 0.66, CI 0.49–0.88, P < 0.001) models in the overall analysis. Subgroup analyses indicated significant association of rs1800896 SNP by dominant (OR 0.45, CI 0.28–0.72, P < 0.001) and heterozygote (OR 0.43, CI 0.26–0.70, P < 0.001) models in the African population. The IL-10 rs1800896 SNP confers protection against the risk of asthma, especially in Africans. Additionally, rs1800871 SNP has a protective role against asthma in Europeans.
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All data generated or analyzed during this study are included in this article.
Abbreviations
- IL-10 :
-
Interleukin-10
- SNP:
-
Single-nucleotide polymorphism
- IL:
-
Interleukin
- PRISMA:
-
Preferred Reporting Items for Systematic reviews and Meta-Analyses
- NOS:
-
Newcastle–Ottawa Scale
- OR:
-
Odds ratio
- CI:
-
Confidence interval
- AHR:
-
Airway hyperresponsiveness
- Ig:
-
Immunoglobulin
- Th2:
-
Helper T
- Treg:
-
Regulatory T
- IBS:
-
Irritable bowel syndrome
- HWE:
-
Hardy–Weinberg equilibrium
- FEM:
-
Fixed-effect model
- REM:
-
Random-effects models
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The authors thank Mr. Karim Imani for all his support.
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DI and ND generated the idea. AP, SH, and BR searched the literature and analyzed and interpreted the data. FA, SS, and MHH prepared the original draft. MA, ND, BR, MM, and SA wrote and critically revised the paper. DI supervised the project. All authors read and approved the final manuscript.
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Imani, D., Dashti, N., Parvari, A. et al. Interleukin-10 Gene Promoter Polymorphisms and Susceptibility to Asthma: Systematic Review and Meta-analysis. Biochem Genet 59, 1089–1115 (2021). https://doi.org/10.1007/s10528-021-10056-9
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DOI: https://doi.org/10.1007/s10528-021-10056-9