Skip to main content


Log in

Unleash the Association of Mitochondrial Uncoupling Protein (UCP2) Promoter Variant (G-866A; rs659366) with Obesity: Stepping from a Case–Control Study to a Meta-analysis

  • Original Article
  • Published:
Biochemical Genetics Aims and scope Submit manuscript


Numerous eligible articles investigated the potential impact of the promoter region of UCP2 (rs659366) variant and the susceptibility for obesity with questionable outcomes. Our team designed this case–control combined with meta-analysis survey to illustrate the contribution of this variant with obesity. This case–control survey was formulated based on 110 obese Egyptian patients and 122 non-obese controls. Genomic DNA was amplified for ascertaining of UCP2 (G-866A; rs659366) variant exploiting the PCR–RFLP technique. A literature search was completed to investigate the involvement of this variant with obesity from various genetic databases. In this case–control study, the distribution of UCP2 (rs659366) variant showed a significant association with obesity among Egyptian subjects under allelic and dominant models (P value = 0.0006 and < 0.001, respectively). Overall, twenty-five comparisons for this variant (8652 obese patients and 10,075 non-obese controls) were recruited in this meta-analysis survey. A noteworthy association of UCP2 (rs659366) variant with obesity was identified among Asians and Africans but not Caucasians under allelic, dominant as well as heterozygote models. Nevertheless, this meta-analysis could not accomplish a noticeable association with overall subjects under different genetic models. This case-controlled study revealed a robust association for UCP2 (rs659366) variant with obesity susceptibility in Egyptian subjects; however, this meta-analysis survey failed to achieve an association for this variant with obesity in overall subjects except among Asians and Africans.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Subscribe and save

Springer+ Basic
EUR 32.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or Ebook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others


Download references


The authors are appreciative for the staff members of Specialized Medical Hospital, Mansoura University, Mansoura, Egypt, for their support in choosing participants enrolled in this study.

Author information

Authors and Affiliations



Conceptualization: RE and HA-D; Methodology: AE, LL, and RE; Software: RE and ET; Validation, AM, and MEl-E; Formal analysis: AM and LL; Investigation: HA-D; Resources: RE and LL; Data curation: RE; Writing—original draft preparation: AM and LL; Writing—review and editing: RE and ET; Visualization: ET and ME-E; Supervision: RE and ET; Project administration: RE.

Corresponding author

Correspondence to Rami M. Elshazli.

Ethics declarations

Conflict of interest

The authors declare that they have no potential conflict of interest related to this study.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Abd El Daim, H.A., Elsaid, A.M., Mousa, A.A. et al. Unleash the Association of Mitochondrial Uncoupling Protein (UCP2) Promoter Variant (G-866A; rs659366) with Obesity: Stepping from a Case–Control Study to a Meta-analysis. Biochem Genet 58, 738–770 (2020).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: