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Association Between Genetic Variants of Akt1 and Endometrial Cancer

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Abstract

Akt isoforms have critical roles in the cause and regulation of cancer cells invasive, migration, and metastatic dissemination. In the present study, the association between Akt1 polymorphisms and endometrial cancer was investigated in patients with endometrial cancer and controls. Thirty premenopaused patients diagnosed with endometrial cancer and 30 premenopaused women with no clinically documented abnormalities of the endometrium undergoing hysterectomy were included in this study. Genotypes were determined by polymerase chain reaction and restriction fragment length polymorphism. There was no significant difference between Akt1 gene polymorphisms of patients (SNP1, SNP2 and SNP3) with endometrial cancer and controls (p > 0.05). Difference between alleles frequency of SNP1, SNP2, SNP3 of patients with endometrial cancer and controls was not significant (p > 0.05). SNPs (rs72715985), (rs2494750), and (rs74090038) of Akt1 gene are not associated with endometrial cancer in Iranian subjects.

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Acknowledgement

The authors thank the Research Deputy of Iran University of Medical Science for funding of this project and thank Arash Hospital in the East of Tehran for recruiting the patients.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Medicine, Iran University of Medical Sciences, 14155-5983, Tehran, Iran

    Soudabeh Fallah & Milad Hajimirza

  2. Research Center of Pediatric Infectious Disease, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran

    Soudabeh Fallah

  3. Department of Biochemistry, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran

    Mohsen Korani

  4. Department of Medical Genetics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada

    Morteza Seifi

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  1. Soudabeh Fallah
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  2. Mohsen Korani
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  3. Milad Hajimirza
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  4. Morteza Seifi
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Correspondence to Soudabeh Fallah.

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Fallah, S., Korani, M., Hajimirza, M. et al. Association Between Genetic Variants of Akt1 and Endometrial Cancer. Biochem Genet 53, 281–290 (2015). https://doi.org/10.1007/s10528-015-9690-0

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  • DOI: https://doi.org/10.1007/s10528-015-9690-0

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