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Polymorphisms of the Resistin Gene and Their Association with Obesity and Resistin Levels in Malaysian Malays

Biochemical Genetics volume 53, pages 120–131 (2015)Cite this article

Abstract

Single nucleotide polymorphisms (SNP) in the resistin gene (RETN) are linked to obesity and resistin levels in various populations. However, results have been inconsistent. This study aimed to investigate association between polymorphisms in the resistin gene with obesity in a homogenous Malaysian Malay population. This study is also aimed to determine association between resistin levels with certain SNPs and haplotypes of RETN. A total of 631 Malaysian Malay subjects were included in this study and genotyping was carried out using Sequenom MassARRAY. There was no significant difference found in both allelic and genotype frequencies of each of the RETN SNPs between the obese and non-obese groups after Bonferroni correction. RETN rs34861192 and rs3219175 SNPs were significantly associated with log-resistin levels. The GG genotype carriers are found to have higher levels of log-resistin compared to A allele carriers. The RETN haplotypes (CAG, CGA and GA) were significantly associated with resistin levels. However, the haplotypes of the RETN gene were not associated with obesity. Resistin levels were not correlated to metabolic parameters such as body weight, waist circumference, body mass index, and lipid parameters. RETN SNPs and haplotypes are of apparent functional importance in the regulation of resistin levels but are not correlated with obesity and related markers.

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Acknowledgments

This study was supported by research Grants HIR-MOHE E000049-20001 and FL009-2011. We would like to thank all the participants of this research.

Conflict of interest

The authors declare no conflict of interest.

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Affiliations

  1. Pharmacogenomics Laboratory, Department of Pharmacology, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Yamunah Devi Apalasamy & Zahurin Mohamed

  2. Julius Centre University of Malaya, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia

    Sanjay Rampal, Foong Ming Moy & Awang Bulgiba

  3. Department of Mathematics and Statistics, La Trobe University, Bundoora, VIC, 3086, Australia

    Agus Salim

  4. Centre for Population Health, Department of Social and Preventive Medicine, University of Malaya, Kuala Lumpur, Malaysia

    Tin Tin Su & Hazreen Abdul Majid

Authors
  1. Yamunah Devi Apalasamy
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  2. Sanjay Rampal
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  4. Foong Ming Moy
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  5. Tin Tin Su
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  6. Hazreen Abdul Majid
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Correspondence to Yamunah Devi Apalasamy.

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Apalasamy, Y.D., Rampal, S., Salim, A. et al. Polymorphisms of the Resistin Gene and Their Association with Obesity and Resistin Levels in Malaysian Malays. Biochem Genet 53, 120–131 (2015). https://doi.org/10.1007/s10528-015-9678-9

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  • DOI: https://doi.org/10.1007/s10528-015-9678-9

Keywords

  • Body mass index
  • RETN
  • BMI
  • Obesity haplotypes