Abstract
Associations with type 2 diabetes mellitus have been identified for variants CDKAL1 rs7756992, KCNJ11 rs5219, and IGF2BP2 rs4402960 in different populations. In a case–control study of 250 unrelated Moroccan diabetic patients and 250 healthy controls, we used TaqMan allelic discrimination assays to genotype the three SNPs and meta-analysis to investigate the association between the polymorphisms and diabetes in Arab populations. The results showed a significant diabetes association only with the variant rs4402960 of the IGF2BP2 gene under additive 2 (GG vs. TT; p = 0.009) and recessive (TT vs. GG+GT; p = 0.003) models. Meta-analysis indicated significant association between the IGF2BP2 rs4402960 and CDKAL1 rs7756992 polymorphisms and increased risk of diabetes in Arab populations. According to our results, the case–control study and meta-analysis revealed a significant association between the IGF2BP2 rs4402960 variant and type 2 diabetes in Moroccan and Arab populations.
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Acknowledgments
This work was supported by NEPAD/NABNet New Partnership for Africa’s Development, North Africa Biosciences Network, and Joint WHO/EMRO-COMSTECH RAB&GH grants. The authors gratefully acknowledge the patients with diabetes and their families for their participation in this study.
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Houda Benrahma and Hicham Charoute contributed equally to this work.
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Benrahma, H., Charoute, H., Lasram, K. et al. Association Analysis of IGF2BP2, KCNJ11, and CDKAL1 Polymorphisms with Type 2 Diabetes Mellitus in a Moroccan Population: A Case–Control Study and Meta-analysis. Biochem Genet 52, 430–442 (2014). https://doi.org/10.1007/s10528-014-9658-5
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DOI: https://doi.org/10.1007/s10528-014-9658-5