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Association of Lymphotoxin Alpha Polymorphism with Type 1 Diabetes in a Tunisian Population

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Abstract

We investigated the association of the lymphotoxin (LT)-α gene polymorphism +249A/G with type 1 diabetes. The distribution of genotypes of the LT-α +249A/G single nucleotide polymorphism (SNP) was assessed in 115 diabetic patients and 123 normoglycemic control subjects, using PCR-restriction fragment length polymorphism analysis. Among unselected patients, the SNP was significantly associated with increased risk of diabetes (χ2 = 8.44, p = 0.014) and was found to be more pronounced among female (χ2 = 8.37, p = 0.02) than male (χ2 = 6.11, p = 0.047) patients. A significant association was detected between LT-α +249A/G and increased risk of diabetes, in particular for young-onset patients (χ2 = 6.92, p = 0.031). Moreover, we reported significant differences in levels of HbA1c, triglycerides, alanine transaminase, and anti-glutamic acid decarboxylase-65 among alleles. Additional studies with extended patient age groups and different ethnicities are needed to confirm our findings.

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Authors and Affiliations

  1. Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Tunis, Tunisia

    Mouna Stayoussef, Jihen Ben Mansour & Touhami Mahjoub

  2. Laboratoire Microorganismes et Biomolécules Actives, Sciences Faculty, Tunis El-Manar University, 2092, Tunis, Tunisia

    Ines Zidi

  3. Laboratory of Molecular and Cellular Hematology, Pasteur Institute of Tunis, Tunis El-Manar University, Tunis, Tunisia

    Imen Moumni

  4. College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain

    Wassim Y. Almawi

Authors
  1. Mouna Stayoussef
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  2. Ines Zidi
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  3. Jihen Ben Mansour
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  4. Imen Moumni
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  5. Wassim Y. Almawi
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  6. Touhami Mahjoub
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Correspondence to Ines Zidi.

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M. Stayoussef and I. Zidi contributed equally to this work.

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Stayoussef, M., Zidi, I., Mansour, J.B. et al. Association of Lymphotoxin Alpha Polymorphism with Type 1 Diabetes in a Tunisian Population. Biochem Genet 52, 79–89 (2014). https://doi.org/10.1007/s10528-013-9629-2

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  • DOI: https://doi.org/10.1007/s10528-013-9629-2

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