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Neurexophilin 1 Gene Polymorphism in Chickens and Its Variation Among Species

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Abstract

Neurexophilin 1 (nxph1) has been considered a potential candidate marker for sperm storage in chicken sperm storage tubules. In this work, one mutation of chicken nxph1 was detected. We analyzed 18 nxph1 gene sequences from 18 species. The coding sequence length of the zebra fish nxph1 gene is 819 bp; that of the other species is 816 bp. Amino acid alignment analysis revealed that the gene product is a conserved protein, especially in mammals. The sequences of mammals are highly conserved. We found 202 conserved amino acids (70–271), and there were only eight mutations in the remaining 69 amino acids. That level of conservation could be due to the nxph1 gene having been subjected to substantial constraints or strong purifying selection during millions of years of evolution.

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Acknowledgments

This work was financially supported by National Natural Science Foundation of China (31071088).

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Authors and Affiliations

  1. College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan, 430070, China

    Guiqiong Liu, Xunping Jiang, Chunbo He & Zhou Tang

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  1. Guiqiong Liu
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  2. Xunping Jiang
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  3. Chunbo He
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  4. Zhou Tang
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Correspondence to Xunping Jiang.

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Liu, G., Jiang, X., He, C. et al. Neurexophilin 1 Gene Polymorphism in Chickens and Its Variation Among Species. Biochem Genet 51, 618–625 (2013). https://doi.org/10.1007/s10528-013-9591-z

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  • DOI: https://doi.org/10.1007/s10528-013-9591-z

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