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Genetic Variability of PXR in Saudi Arabians

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An Erratum to this article was published on 13 December 2013

Abstract

Polymorphisms in the PXR gene play important roles in influencing the efficacy and toxicity of a large number of endogenous and exogenous substrates. Because of ethnic specificity, several studies have been directed toward the determination of PXR polymorphisms in various populations. In the current study, we determined the genotype and allele frequencies of 19 coding and regulatory polymorphisms in the PXR gene in Saudi Arabians by direct sequencing. Our results show that the frequencies of the regulatory PXR SNPs in Saudi Arabians differ from those in other ethnic groups, and the results endorse the commonly seen ethnic pattern of a paucity of the PXR coding SNPs.

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Acknowledgments

This study was supported by the National Plan for Sciences and Technology Program (grant 08-MED565-02), King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.

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Authors and Affiliations

  1. Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Saudi Arabia

    Mohammed S. Al-Dosari & M. Khalid Parvez

  2. Clinical Pharmacy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

    Khalid M. Alkharfy

  3. Biomarkers Research Program, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

    Khalid M. Alkharfy

  4. Department of Pediatrics, Asthma Research Chair and Prince Naif Center for Immunology Research, College of Medicine, King Saud University, Riyadh, Saudi Arabia

    Amal M. Alghamdi, Saleh Al-Muhsen & Rabih Halwani

  5. Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

    Abdullah M. Al-Mohizea & Fahad I. Al-Jenoobi

Authors
  1. Mohammed S. Al-Dosari
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  2. Khalid M. Alkharfy
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  3. Amal M. Alghamdi
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  4. Abdullah M. Al-Mohizea
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  5. Fahad I. Al-Jenoobi
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  6. Saleh Al-Muhsen
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  7. Rabih Halwani
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  8. M. Khalid Parvez
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Correspondence to Mohammed S. Al-Dosari.

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Al-Dosari, M.S., Alkharfy, K.M., Alghamdi, A.M. et al. Genetic Variability of PXR in Saudi Arabians. Biochem Genet 51, 575–587 (2013). https://doi.org/10.1007/s10528-013-9588-7

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  • DOI: https://doi.org/10.1007/s10528-013-9588-7

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