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A 45-bp Insertion/Deletion Polymorphism in Uncoupling Protein 2 is Not Associated with Obesity in a Chinese Population

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The association of a 45-bp insertion/deletion (UCP2-45 bp I/D) polymorphism in uncoupling protein 2 with body mass index (BMI) remains controversial. A case–control study was conducted to examine the association in a Chinese population. The 1,526 subjects recruited in downtown Beijing and genotyped included 616 obese subjects with BMI >28 and 910 age- and gender-matched controls with BMI <24. The association of the polymorphisms with obesity was estimated using multivariate logistic regression in three models of inheritance. The odds ratios were 1.08 (95 % CI 0.846–1.368; P = 0.551) in the dominant model, 0.931 (0.751–1.154; P = 0.513) in the additive model, and 1.18 (0.550–2.550; P = 0.666) in the recessive model. The overall comparison of the genotype distributions in obese and control subjects using the chi-square test yielded P = 0.801. Our study demonstrated no association between UCP2-45 bp I/D and BMI variation in the Chinese population.

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The authors are grateful to the community, especially the recruited participants, for taking part in this study. We appreciate the invaluable help from our associates during the collection of blood samples and biochemical analyses. This study was supported by the Beijing Hypertension League Institute, in part through an unrestricted educational grant from F. Hoffmann-La Roche to the National Infrastructure Program of Chinese Genetic Resources (2005DKA21300).

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Correspondence to Jingbo Zhao or Xingyu Wang.

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Xiaoqiu Liu and Bin Zhang contributed equally to this paper.

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Liu, X., Zhang, B., Liu, X. et al. A 45-bp Insertion/Deletion Polymorphism in Uncoupling Protein 2 is Not Associated with Obesity in a Chinese Population. Biochem Genet 50, 784–796 (2012).

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