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Polymorphism of the Apolipoprotein B Gene and Association with Plasma Lipid and Lipoprotein Levels in the Mongolian Buryat

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Abstract

Allele frequencies at six RFLP sites (Ins/Del, ApaLI, AluI, XbaI, MspI, and EcoRI) of the apolipoprotein B gene (APOB) and the relationship of genotypes with plasma lipid and lipoprotein levels in the Mongolian Buryat were investigated. Common alleles at these sites in 110 Buryat subjects were I, G, A−, X−, M+, and E+; the frequencies of 0.809–0.991 differed strikingly from those of a few Asians and most Europeans. Five unambiguous haplotypes of all sites were revealed at 74%; haplotype IGA−X−M+E+ (000000) was the most frequent (67%), followed by IGA+X−M+E+ (001000) (19%). The frequency constitution differed significantly from the Chinese, Malaysians, and Caucasians but resembled the Indians. No APOB polymorphisms were associated with cholesterol levels (total, HDL and LDL). Significant associations of genotypes were shown with the triglyceride level only at the AluI and XbaI sites. The lipid level of A−A+ females or X−X+ males was higher than that of A−A− females or X−X− males, respectively.

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  1. Kenji Tsunoda

    Present address: Nagoya Institute of Animal Science, Yokohama, 225-0014, Japan

Authors and Affiliations

  1. Department of Legal Medicine, Showa University School of Medicine, Tokyo, 142-8555, Japan

    Kenji Tsunoda

  2. Graduate School of Science, University of Tokyo, Tokyo, 113-0033, Japan

    Shinji Harihara

  3. Faculty of Agriculture, Gifu University, Gifu, 501-1112, Japan

    Yuichi Tanabe

  4. Institute of Biotechnology, Mongolian Academy of Sciences, Ulaanbaatar 51, Mongolia

    Bumbein Dashnyam

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  1. Kenji Tsunoda
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  2. Shinji Harihara
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Correspondence to Kenji Tsunoda.

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Tsunoda, K., Harihara, S., Tanabe, Y. et al. Polymorphism of the Apolipoprotein B Gene and Association with Plasma Lipid and Lipoprotein Levels in the Mongolian Buryat. Biochem Genet 50, 249–268 (2012). https://doi.org/10.1007/s10528-011-9468-y

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