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CTLA4 A49G Polymorphism Shows Significant Association With Glioma Risk in a Chinese Population

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Abstract

Cytotoxic T lymphocyte-associated antigen-4 (CTLA4) A49G is a polymorphism that is extensively studied in various cancers. To investigate whether it is associated with the occurrence of glioma in Chinese patients, we performed a case–control research study with 670 patients and 680 controls. In this group, we found that the genotype at this locus is significantly associated with glioma risk (GG vs. AA: P = 0.045; GG + AG vs. AA: P = 0.013). In some subgroups, G allele carriers are significantly less represented. We also observed significant correlations between the polymorphism genotype and glioma risk in patients with WHO histologic stages. We conclude that CTLA4 A49G might be a potential clinical biomarker for distinguishing persons with a high risk for developing gliomas.

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Acknowledgments

This work was supported by China National Key Basic Research Program Grants (2002CB512902), National 211 Environmental Genomics Grant. We thank all the patients and individuals for their participation, the clinicians and other hospital staff, cancer registries, and study staff.

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Authors and Affiliations

  1. School of Life Science, East China Normal University, Shanghai, 200062, China

    Qihan Wu, Xiaoying Zhan, Hongxia Zheng, Yanyan Cai & Daru Lu

  2. State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University, Handan Rd, Shanghai, 200433, China

    Tonghai Dou, Hongyan Chen, Weiwei Fan & Daru Lu

  3. Neurosurgery Department, Huashan Hospital, Fudan University, 12 Wulumuqi Zhong Rd, Shanghai, 200040, China

    Keke Zhou, Haishi Zhang, Yao Zhao, Fengping Huang, Liangfu Zhou & Ying Mao

Authors
  1. Qihan Wu
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  2. Xiaoying Zhan
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  3. Tonghai Dou
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  4. Hongyan Chen
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  5. Weiwei Fan
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  7. Haishi Zhang
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  9. Yanyan Cai
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  10. Yao Zhao
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  11. Fengping Huang
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  12. Liangfu Zhou
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  13. Ying Mao
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  14. Daru Lu
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Correspondence to Ying Mao or Daru Lu.

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Qihan Wu, Xiaoying Zhan, and Tonghai Dou contributed equally to this work.

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Wu, Q., Zhan, X., Dou, T. et al. CTLA4 A49G Polymorphism Shows Significant Association With Glioma Risk in a Chinese Population. Biochem Genet 49, 190–201 (2011). https://doi.org/10.1007/s10528-010-9398-0

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  • DOI: https://doi.org/10.1007/s10528-010-9398-0

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