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Prevalence of the Angiotensin I Converting Enzyme Gene Insertion/Deletion Polymorphism in a Healthy Turkish Population

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Abstract

Angiotensin converting enzyme (ACE) plays an essential role in the renin–angiotensin system. It converts angiotensin I to angiotensin II and inactivates bradykinin and tachykinins. Numerous studies have been published investigating associations of the ACE gene I/D polymorphism with various pathophysiological conditions. We examined the prevalence of the ACE I/D polymorphism in a sample of healthy volunteers from western Turkey, including 1063 healthy Turkish controls. Analysis of the ACE I/D gene polymorphisms by polymerase chain reaction found frequencies of 16.1% for the II genotype, 47.7% for the ID genotype, and 36.2% for the DD genotype. The allele frequency was 39.9% for the I alleles and 60.1% for the D allele. This study demonstrates that the allele and genotype frequency values for the Turkish population are similar to previously published frequencies for Caucasian populations.

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  1. Molecular Medicine Laboratory, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey

    Afig Berdeli

  2. Department of Medical Genetics, Faculty of Medicine, Celal Bayar University, Manisa, Turkey

    F. Sirri Cam

  3. Ilica M. Tur S. 9 Eylul Sitesi, Nilufer Apt. No: 4/8, 35320, Narlidere, Izmir, Turkey

    F. Sirri Cam

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  1. Afig Berdeli
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Berdeli, A., Cam, F.S. Prevalence of the Angiotensin I Converting Enzyme Gene Insertion/Deletion Polymorphism in a Healthy Turkish Population. Biochem Genet 47, 412–420 (2009). https://doi.org/10.1007/s10528-009-9240-8

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  • DOI: https://doi.org/10.1007/s10528-009-9240-8

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