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Melanocortin-4 Receptor Gene Polymorphisms in Obese Patients

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Abstract

Obesity is a complex disease caused by both genetics and environmental factors. Melanocortin-4 receptor (MC4R) (MIM 155541) gene polymorphisms were reported to be the cause of monogenic obesity in humans. We studied three polymorphisms (Val50Met, Val103Ile, and Ser58Cys) and a mutation (Asn274Ser) of the MC4R gene in 203 obese patients and in 110 healthy subjects in the Turkish population. A high incidence of Val103Ile and Val50Met polymorphisms as well as the Asn274Ser mutation was found in the obese patients, whereas no significant correlation was found regarding the Ser58Cys polymorphism. We conclude that there is a concordance between the polymorphisms (Val103Ile, Val50Met, Ser58Cys) that were first studied in the Turkish population with obesity.

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Authors and Affiliations

  1. Department of Medical Biology and Genetics, Gazi University Faculty of Medicine, Besevler, Ankara, Turkey

    Erkan Yurtcu, Akin Yilmaz & Adnan Menevse

  2. Department of Endocrinology and Metabolism, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey

    Zubeyde Ozkurt, Emine Kolukisa, Murat Yilmaz & Hatice Keles

  3. Department of Medical Genetics, Gazi University Faculty of Medicine, Ankara, Turkey

    Mehmet Ali Ergun

  4. Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey

    Ilhan Yetkin

Authors
  1. Erkan Yurtcu
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  2. Akin Yilmaz
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  3. Zubeyde Ozkurt
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  4. Emine Kolukisa
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  5. Murat Yilmaz
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  6. Hatice Keles
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  7. Mehmet Ali Ergun
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  8. Ilhan Yetkin
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  9. Adnan Menevse
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Correspondence to Adnan Menevse.

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Yurtcu, E., Yilmaz, A., Ozkurt, Z. et al. Melanocortin-4 Receptor Gene Polymorphisms in Obese Patients. Biochem Genet 47, 295–300 (2009). https://doi.org/10.1007/s10528-009-9228-4

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  • DOI: https://doi.org/10.1007/s10528-009-9228-4

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