A method and a device for digital laser Doppler flowmetry are proposed. An approach to signal processing based on analysis of the power spectrum amplitude distribution over Doppler broadening frequencies is suggested. A prototype of the device is presented; its technical characteristics and settings used in tests are described. The method was tested in healthy volunteers of different ages and patients with type 2 diabetes mellitus. The research led to the development of binary classifiers for classifying volunteers and patients into groups according to the functional state of microcirculation.
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References
Cummins, H. Z. and Swinney, H. L., III Light Beating Spectroscopy, Vol. 8, Elsevier (1970), pp. 133-200.
Forrester, A. T., “Photoelectric mixing as a spectroscopic tool,” J. Opt. Soc. Am. OSA, 51, No. 3, 253-259 (1961).
Leahy, M. J. and Nilsson, G. E., “Laser Doppler flowmetry for assessment of tissue microcirculation: 30 years to clinical acceptance,” Proc. SPIE, 7563, 75630E-75630E-5 (2010).
Kvandal, P., Landsverk, S. A., Bernjak, A., Stefanovska, A., Kvernmo, H. D., and Kirkebøen, K. A., “Low-frequency oscillations of the laser Doppler perfusion signal in human skin,” Microvasc. Res., 72, No. 3, 120 (2006).
Mizeva, I., Zharkikh, E., Dremin, V., Zherebtsov, E., Makovik, I., Potapova, E., and Dunaev, A., “Spectral analysis of the blood flow in the foot microvascular bed during thermal testing in patients with diabetes mellitus,” Microvasc. Res., 120, 13-20 (2018).
Stefanovska, A., Bracic, M., and Kvernmo, H. D., “Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique,” IEEE Trans. Biomed. Eng., 46, No. 10, 1230-1239 (1999).
Dremin, V., Zherebtsov, E., Makovik, I., Kozlov, I., Sidorov, V., Krupatkin, A., Dunaev, A., Rafailov, I., Litvinova, K., Sokolovski, S., and Rafailov, E., “Laser Doppler flowmetry in blood and lymph monitoring, technical aspects and analysis,” Proc. SPIE, 10063, 10063-03-10063-08 (2017).
Zherebtsov, E. A., Zharkikh, E. V., Kozlov, I. O., Loktionova, Y. I., Zherebtsova, A. I., Rafailov, I. E., Sokolovski, S. G., Sidorov, V. V., Dunaev, A. V., and Rafailov, E. U., “Wearable sensor system for multipoint measurements of blood perfusion: Pilot studies in patients with diabetes mellitus,” in: Clinical and Preclinical Optical Diagnostics II. Proc. SPIE (Optical Society of America), Paper No. 11079-62 (2019).
Fredriksson, I., Larsson, M., and Strömberg, T., “Model-based quantitative laser Doppler flowmetry in skin,” J. Biomed. Opt., 15, No. 5, 57002-57012 (2010).
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Translated from Meditsinskaya Tekhnika, Vol. 55, No. 1, Jan.–Feb., 2021, pp. 8–11.
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Kozlov, I.O., Zherebtsov, E.A., Podmasteryev, K.V. et al. Digital Laser Doppler Flowmetry: Device, Signal Processing Technique, and Clinical Testing. Biomed Eng 55, 12–16 (2021). https://doi.org/10.1007/s10527-021-10061-7
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DOI: https://doi.org/10.1007/s10527-021-10061-7