The regenerative capacity of articular cartilage was assessed after injection of Matricin polyacrylamide-hyaluronic gel into the knee joints of nine rabbits with a model of osteoarthrosis. Matricin decreased dystrophic and destructive changes in articular cartilage previously induced by exposure to papain solution and produced a significant increase in the regenerative capacity of the damaged hyaline cartilage.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Clinical Recommendations. Rheumatology [in Russian], Nasonov, E. L. (ed.), GEOTAR-Media, Moscow (2005), pp, 99-111.
Towheed, T. E., Maxwell, L., Judd, M. G., Catton, M., Hochberg, M. C., and Wells, G., “Acetaminophen for osteoarthritis,” Cochrane Database Syst. Rev., CD004257 (2003).
Hochberg, M. C. and Clegg, D. O., “Potential effects of chondroitin sulfate on joint swelling: A GAIT report,” Osteoarthr. Cart., 16. Suppl. 3, 22-24 (2008).
Gerasimenko, A. Yu., Zhurbina, N. N., Kurilova, U. E., Ichkitidze, L. P., Selishchev, S. V., Suetina, I. A., Mezentseva, M. A., Russu, L. I., Zar, V. V., and Podgaetskii, V. M., “Knee joint ligament implants with composite nanocoatings,” Biomed. Eng., 50, No. 3, 206-209 (2016).
Brandt, K. D., Mazzuca, S. A., and Katz, B. P., “Effects of doxycycline on progression of osteoarthritis: Results of a randomized, placebo-controlled, double-blind trial,” Arthritis Rheum., 52, 2015-2025 (2005).
Balazs, E. A. and Denlinger, J. L., “Viscosupplementation: A new concept in the treatment of osteoarthritis,” J. Rheumatol., 39, 3-9 (1993).
Shekhter, A. B., Zar, V. V., Voloshin, V. P., and Lopatin, V. V., “Tissue and cell reactions of the synovial medium to intraarticu lar administration of the polymer viscoprosthesis Noltrex in experimental conditions,” Al’m. Klin. Med., No. 28, 20-24 (2013).
Zar, V. V., Voloshin, V. P., and Martynov, M. D., “Functional assessment of the results of intraarticular administration of Noltrex polyacrylamide gel in the treatment of patients with gonarthrosis,” Al’m. Klin. Med., No. 27, 18-24 (2012).
Lopatin, V. V., Belonenko, V. N., Zar, V. V., and Askadskii, A. A., “Comparative studies of the mechanical behavior of human joint fluid and polyacrylamide hydrogel depending on pressure,” Plast. Massy, No. 7, 24-29 (2004).
Lopatin, V. V, et al., “Swelling of medical polyacrylamide gels,” Vysokomol. Soedin. Ser. A, No. 7, 1187-1195 (2005).
Vlasov, V. I., Kuznetsova, E. A., Lopatin, V. I., and Dar’evich, E. N., The Medical Material ‘Matrexin’ Based on Polyacrylamide Gel and Means for Its Preparation (variants), RF Patent 2545806: No. 2013157847/15; April 10, 2015; Byul. No. 10, 1-17.
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Meditsinskaya Tekhnika, Vol. 53, No. 4, Jul.-Aug., 2019, pp. 14-16.
Rights and permissions
About this article
Cite this article
Zar, V.V., Shekhter, A.B., Sukhanov, E.N. et al. Regeneration of Articular Cartilage in Experimental Osteoarthrosis after Injection of a Complex Polyacrylamide-Hyaluronic Gel. Biomed Eng 53, 244–248 (2019). https://doi.org/10.1007/s10527-019-09918-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10527-019-09918-9