Skip to main content
SpringerLink
Log in

Chemical Linking of Albumin to the Surface of Ion Beam-Modified Polyurethane Implants

  • Published:
Biomedical Engineering Aims and scope

Polyurethane with a low modulus of elasticity for implantation into soft tissues was synthesized. Polyurethane was treated with nitrogen ions with energy 20 keV, which created a graphite-like layer on the surface of thickness about 56 nm, with active free radicals on the edges of the graphite planes. This resulted in covalent binding of a monolayer of albumin on the treated polyurethane surface as a result of free radical reactions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Kannan, R. Y., Salacinski, H. J., Butler, P. E., Hamilton, G., and Seifalian, A. M., “Current status of prosthetic bypass grafts: A review,” J. Biomed. Mat. Res. B Appl. Biomat., 74, 570-581 (2005).

    Article  Google Scholar 

  2. Ballyk, P. D., Walsh, C., Butany, J., and Ojha, M., “Compliance mismatch may promote graftartery intimal hyperplasia by altering suture-line stresses,” J. Biomech., 31, 229-237 (1998).

    Article  Google Scholar 

  3. Begishev, V., Gavrilov, N., Mesyats, G., Klyachkin, Yu., Kondyurina, I., Kondyurin, A., and Osorgina, I., “Modification of polyurethane endoprosthetics surface by pulse ion beam,” in Proc. 12th Int. Conf. on High-Power Particle Beams, Haifa, Israel, June 7-12, 1998, M. Markovits and J. Shiloh (eds.), Vol. 2, pp. 997-1000.

  4. Kondyurin, A. and Maitz, M. F., “Surface modification of ePTFE and implants using the same,” US patent WO 2007/022174 A3 (2007).

  5. Kondyurina, I., Shardakov, I., Nechitailo, G., Terpugov, V., and Kondyurin, A., “Cell growing on ion implanted polytetrafluorethylene,” Applied Surface Science, 314, 670-678 (2014).

    Article  Google Scholar 

  6. Kanyanta, V. and Ivankovic, A., “Mechanical characterization of polyurethane elastomer for biomedical applications,” J. Mech. Behav. Biomed. Mat., 3, 51-62 (2010).

    Article  Google Scholar 

  7. Gorna, K. and Gogolewski, S., “Molecular stability, mechanical properties, surface characteristics and sterility of biodegradable polyurethanes treated with low-temperature plasma,” Polymer Degradation and Stability, 79, 475-485 (2003).

    Article  Google Scholar 

  8. Akhtar, R., Sherratt, M. J., Cruickshank, J. K., and Derby, B., “Characterizing the elastic properties of tissues,” Materials Today, 14, No. 3, 96-105 (2011).

    Article  Google Scholar 

  9. Ahn, B. and Kim, J., “Measurement and characterization of soft tissue behavior with surface deformation and force response under large deformations,” Medical Image Analysis, 14, 138-148 (2010).

    Article  Google Scholar 

  10. Bergstrom, J. S. and Boyce, M. C., “Constitutive modelling of the time-dependent and cyclic loading of elastomers and application to soft biological tissues,” Mechanics of Materials, 33, 523-530 (2001).

    Article  Google Scholar 

  11. Wells, S. M. and Walter, E. J., “Changes in the mechanical properties and residual strain of elastic tissue in the developing fetal aorta,” Ann. Biomech. Eng., 38, No. 2, 345-356 (2010).

    Article  Google Scholar 

  12. Ferrari, A. C. and Robertson, J., “Interpretation of Raman spectra of disordered and amorphous carbon,” Phys. Rev. B, 61, 14,095-14,107 (2000).

    Google Scholar 

  13. Ferrari, A. C. and Basko, D. M., “Raman spectroscopy as a versa-tile tool for studying the properties of graphene,” Nat. Nanotechnol., 8, 235-246 (2013).

    Article  Google Scholar 

  14. Hong, W., Woo, H.-J., Choi, H.-W., Kim, Y.-S., and Kim, G.-D., “Optical property modification of PMMA by ion-beam implantation,” Applied Surface Science, 169-170, 428-432 (2001).

    Article  Google Scholar 

  15. Gavrilov, N. V., Mizgulin, V. N., Stinnett, R., and Kondyurin, A. V., “Modification of PE, PTFE, PC, and PI with pulsed ion beams,” Khim. Fiz. Mezoskop., 1, No. 1, 39-47 (1999).

    Google Scholar 

  16. Kondyurina, I. V., Nechitailo, G. S., and Kondyurin, A. V., “Ion beam modification of polytetrafluoroethylene and cell adhesion,” Plastich. Massy, No. 1, 15-21 (2011).

Download references

Author information

Authors and Affiliations

  1. Sydney Medical School, University of Sydney, Sydney, Australia

    I. V. Kondyurina

  2. Institute of Continuous Media Mechanics of the Ural Branch of the Russian Academy of Sciences (ICMM UB RAS), Perm, Russia

    V. S. Chudinov

  3. Department of the Continuum Media Mechanics and Computational Technologies, Perm State University, Perm, Russia

    V. S. Chudinov & V. N. Terpugov

  4. School of Physics, University of Sydney, Sydney, Australia

    A. V. Kondyurin

Authors
  1. I. V. Kondyurina
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. S. Chudinov
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. N. Terpugov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. A. V. Kondyurin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to V. N. Terpugov.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kondyurina, I.V., Chudinov, V.S., Terpugov, V.N. et al. Chemical Linking of Albumin to the Surface of Ion Beam-Modified Polyurethane Implants. Biomed Eng 52, 243–246 (2018). https://doi.org/10.1007/s10527-018-9822-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10527-018-9822-z

Search

Navigation