Activation of reducing processes in biological tissues by exposure to pulse-modulated radio-frequency (RF) currents is studied. It is shown that the weak destructive effect of RF currents activates the process of proliferation of healthy cells. A prototype device for dosed exposure to pulse-modulated RF currents based on needle electrodes is described. The results of experimental animal studies and randomized clinical studies using a purpose-designed prototype device for dosed exposure to pulse-modulated RF currents are presented. The clinical efficacy of dosed RF stimulation for treatment of purulent, inflammatory, and purulent-inflammatory processes is shown to be high.
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References
Buckingham, M., “Myogenic progenitor cells and skeletal myogenesis in vertebrates,” Curr. Opin. Genet. Dev., 16, 525-532 (2006).
Stocum, D. L., Regenerative Biology and Medicine, Acad. Press, New York (2006).
Frolov, S. A., Sushkov, O. I., Pshelenskaya, A. I., Danyleiko, Yu. K., Salyuk, V. A., and Belov, S. V., “Experimental substantiation of the parameters of electrostimulation of processes of open surgical wound healing,” Koloproktol., No. 2 (44), 9-18 (2013).
Balan, O. V., Belov, S. V., Danyleiko, Yu. K., Dubovaya, T. K., Markitantova, Yu. V., Osiko, V. V., Salyuk, V. A., Suhorukov, V. S., and Ozernyuk, N. D., “Activation of repair processes in rat tissues by exposure to periodic pulse-modulated radio-frequency current,” Izv. Ros. Akad. Nauk. Ser, Biol., No. 6, 645-652 (2010).
Balan, O. V., Analysis of in vitro Differentiation of Satellite Cells and Myoblasts Extracted from Skeletal Muscles of Rats at Various Stages of Ontogenesis: Candidate’s Thesis [in Russian], IBR RAN, Moscow (2009).
Pshelenskaya, A. I., Use of High-Frequency Electrostimulation for Treatment of Open Wounds in the Pubic and Sacrococcygeal Regions: Candidate’s Thesis [in Russian], GNTs Koloproktologii, Moscow (2014).
Frolov, S. A., Sushkov, O. I., Maksimova, L. V., Pshelenskaya, A. I., Belov, S. V., Danyleiko, Yu. K., Osiko, V. V., and Salyuk, V. A., “High-frequency electrostimulation of the wound process in patients after surgical treatment of perianal fistula and pilonidal cyst,” Koloproktol., No. 3 (44), 3-7 (2010).
Baburin, N. V., Belov, S. V., Danyleiko, Yu. K., Egorov, A. B., Lebedeva, T. P., Nefedov, S. M., Osiko, V. V., and Salyuk, V. A., “Heterogeneous recombination in water vapor plasma as a mechanism of action on biological tissues,” DAN, 426, No. 4, 1-3 (2009).
Belov, S. V., Danyleiko, Yu. K., Nefedov, S. M., Osiko, V. V., Salyuk, V. A., and Sidorov, V. A., “Specific features of generation of low-temperature plasma in high-frequency plasma electrosurgical apparatuses,” Med. Tekh., No. 2, 26-32 (2011).
Balan, O. V., Markitantova, Y. V., Ozernnyuk, N. D., Belov, S. V., Danileiko, Y. K., Osiko, V. V., Salyuk, V. A., Dubovaya, T. K., and Suhorukov, V. S., “Activation of reconstructive processes in rat tissues under the action of radiofrequency current with a periodic impulse mode of modulation,” Biology Bulletin, 37, No. 6, 551-557 (2010).
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Translated from Meditsinskaya Tekhnika, Vol. 52, No. 2, Mar.-Apr., 2018, pp. 6-9.
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Belov, S.V., Danyleiko, Y.K., Osiko, V.V. et al. A Device for Activation of Tissue Cell Proliferation by Dosed Exposure to Radio-Frequency Currents. Biomed Eng 52, 80–83 (2018). https://doi.org/10.1007/s10527-018-9787-y
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DOI: https://doi.org/10.1007/s10527-018-9787-y