The article considers the production of radionuclides in nuclear reactors and proton accelerators for three main generators, 99Mo/ 99mTc, 82Sr/ 82Rb and 68Ge/ 68Ga, and shows the advantages of using radionuclide generators for production of radiopharmaceuticals. Germanium-68 is manufactured using cyclotrons with an energy of 23-30 MeV. Linear proton accelerators or cyclotrons with an energy of 70-160 MeV are used for production of Rubidium-82.
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Translated from Meditsinskaya Tekhnika, Vol. 49, No. 6, Nov.-Dec., 2015, pp. 1114.
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Pashentsev, V.N. Current State and Prospects of Production of Radionuclide Generators for Medical Diagnosis. Biomed Eng 49, 340–343 (2016). https://doi.org/10.1007/s10527-016-9562-x
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DOI: https://doi.org/10.1007/s10527-016-9562-x