Biophysical mechanisms of formation of nonlinear electric properties of skin are discussed. The possibility of corneal layer monitoring during transdermal delivery of medication, examination of skin moisture, and evaluation of functional and psychoemotional state is demonstrated. The suggested monitoring technique is based on measurements of linear and nonlinear components of electric admittance of skin. As a result of research on the nonlinear equivalent circuit of electric admittance of skin, errors in measurement of its parameters for third-order power series approximation of skin conductance are determined. The interconnections between the relative error of calculation of polynomial coefficients, the electric capacity, the corneal layer hydration rate, and the normalized magnitude of interference caused by near-electrode electrochemical processes, as well as industrial power-line noise, are established.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
O. D. Myadelets and V. P. Adaskevich, Functional Morphology and General Pathology of Skin [in Russian], Vitebsk (1997).
M. R. Prausnitz, Adv. Drug Deliv. Rev., 18, 395–425 (1996).
V. G. Zarnitsyn, M. R. Prausnitz, and Yu. A. Chizmadzhev, Biol. Membr., 21, 355–373 (2004).
V. A. Indenbom, Biol. Membr., 19, 202–208 (2002).
G. K. Johnssen, O. G. Martinsen, and S. Grimnes, ICEBI, IFMBE Proc., 17, 158–160 (2007).
G. K. Johnssen, O. G. Martinsen, and S. Grimnes, ICEBI (2010).
D. G. Beetner, S. Kapoor, S. Manjunath, Z. Xiangyang, and W. V. Stoecker, IEEE Trans. Biomed. Eng., 50, 1020–1025 (2003).
L. T. Neborskii and S. L. Neborskii, Electrocutaneous Conductivity: Its Use in Assessment of the Functional State of Human Body [in Russian], Meditsina, Moscow (2007).
A. A. Aldersons, Mechanisms of Electrodermal Reactions [in Russian], Zinatne, Riga (1985).
A. Jabbari, B. Johnsen, S. Grimnes, and O. G. Martinsen, ICEBI (2010).
T. Yamamoto and Y. Yamamoto, Med. Biol. Eng. Comput., 19, 302–310 (1981).
S. Grimnes, Med. Biol. Eng. Comput., 21, 739–749 (1983).
R. F. Musin, Electric Properties of Epidermis: Candidate dissertation [in Russian], Moscow (1985).
R. R. Burnette and T. M. Bagniefski, J. Pharm. Sci., 77, 492–497 (1988).
R. R. Burnette and B. Ongpipattanakul, J. Pharm. Sci., 77, 132–137 (1988).
G. B. Kasting and L. A. Bowman, Pharm. Res., 7, 134–143 (1990).
S. M. Sims, W. I. Higuchi, and V. Srinivasan, Pharm. Res., 9, 1402–1409 (1992).
S. M. Dinh, C.-W. Luo, and B. Berner, AIChE J., 39, 2011–2018 (1993).
V. A. Indenbom and Yu. A. Chizmadzhev, Biol. Membr., 18, 29–37 (2001).
V. Kh. Shpunt, Med. Tekh., No. 4, 38–47 (1997).
О. G. Martinsen, S. Grimnes, C. A. Lütken, and G. K. Johnsen, ICEBI (2010).
V. A. Karpukhin and A. E. Kosorukov, Med. Tekh., No. 2, 27–30 (2010).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Meditsinskaya Tekhnika, Vol. 47, No. 1, Jan.-Feb., 2013, pp. 32-35.
Rights and permissions
About this article
Cite this article
Karpukhin, V.A., Kosorukov, A.E. Study of a Method for Identification of Parameters of the Nonlinear Equivalent Circuit of Electric Admittance of Skin. Biomed Eng 47, 39–42 (2013). https://doi.org/10.1007/s10527-013-9330-0
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10527-013-9330-0