A rapid method for detection of an optical heterogeneity in a biological object on the basis of diffuse optical tomography (DOT) is described. The method utilizes late arriving photons (LAP) that are scattered and diffusely transmitted through a phantom or a biological object. The technique was validated experimentally using a near infrared femtosecond laser as the source. A streak camera was used as the radiation detector. Satisfactory agreement between the experimental data and a numerical diffusion model is demonstrated. The initial relative number of photons in a single pulse (virtual isotropic source) uniformly fills the object in the same manner as a diffusing droplet moving toward the center of an object.
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Proskurin, S.G., Potlov, A.Y. & Frolov, S.V. Detection of an Absorbing Heterogeneity in a Biological Object during Recording of Scattered Photons. Biomed Eng 46, 219–223 (2013). https://doi.org/10.1007/s10527-013-9310-4
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DOI: https://doi.org/10.1007/s10527-013-9310-4