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Detection of an Absorbing Heterogeneity in a Biological Object during Recording of Scattered Photons

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Biomedical Engineering Aims and scope

A rapid method for detection of an optical heterogeneity in a biological object on the basis of diffuse optical tomography (DOT) is described. The method utilizes late arriving photons (LAP) that are scattered and diffusely transmitted through a phantom or a biological object. The technique was validated experimentally using a near infrared femtosecond laser as the source. A streak camera was used as the radiation detector. Satisfactory agreement between the experimental data and a numerical diffusion model is demonstrated. The initial relative number of photons in a single pulse (virtual isotropic source) uniformly fills the object in the same manner as a diffusing droplet moving toward the center of an object.

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References

  1. S. G. Proskurin, Kvant. Elektron., 41, 402–406 (2011).

    Article  Google Scholar 

  2. T. J. Farrell and M. S. Patterson, Med. Phys., 19, 879–888 (1992).

    Article  Google Scholar 

  3. L. Wang, P. P. Ho, C. Liu, G. Zhang, and R. R. Alfano, Science, 253, 769–771 (1991).

    Article  Google Scholar 

  4. M. Firbank, M. Hiraoka, and D. T. Delpy, Proc. SPIE, 1888, 264–270 (1993).

    Article  Google Scholar 

  5. M. S. Patterson, B. Chance, and B. C. Wilson, Appl. Opt., 28, 2331–2336 (1989).

    Article  Google Scholar 

  6. S. G. Proskurin, Proc. Saratov Fall Meeting SFM’11, Saratov (2011), pp. 27–30.

  7. E. V. Tret’yakov, V. V. Shuvalov, and I. V. Shutov, Kvant. Elektron., 31, 1095–1100 (2001).

    Article  Google Scholar 

  8. B. Chance, S. Nioka, J. Kent, K. McCully, M. Fountain, R. Greenfeld, and G. Holtom, Analyt. Biochem., 174, 698–707 (1988).

    Article  Google Scholar 

  9. M. A. O’Leary, D. A. Boas, B. Chance, and A. G. Yodh, Opt. Lett., 20, 426–428 (1995).

    Article  Google Scholar 

  10. B. W. Pogue, M. S. Patterson, H. Jiang, and K. D. Paulsen, Phys. Med. Biol., 40, 1709–1729 (1995).

    Article  Google Scholar 

  11. E. V. Malikov, V. M. Petnikova, D. A. Chursin, and I. V. Shutov, Kvant. Elektron., 30, 78–80 (2000).

    Article  Google Scholar 

  12. S. G. Proskurin, S. V. Frolov, and A. Yu. Potlov, “Simulation of Light Scattering in Biological Tissue”, State Software Registration Certificate No. 2012615093 (2012).

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Correspondence to S. G. Proskurin.

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Proskurin, S.G., Potlov, A.Y. & Frolov, S.V. Detection of an Absorbing Heterogeneity in a Biological Object during Recording of Scattered Photons. Biomed Eng 46, 219–223 (2013). https://doi.org/10.1007/s10527-013-9310-4

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  • DOI: https://doi.org/10.1007/s10527-013-9310-4

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