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Biology Bulletin

, Volume 32, Issue 4, pp 381–386 | Cite as

Effect of Modification of the N-Terminal Region of Semax on the Expression of Nootropic Effect of Semax Analogs

  • N. Yu. Glazova
  • E. A. Sebentsova
  • N. G. Levitskaya
  • L. A. Andreeva
  • L. Yu. Alfeeva
  • A. A. Kamenskii
  • N. F. Myasoedov
Human and Animal Physiology
  • 37 Downloads

Abstract

A comparative study of nootropic activity of semax (MEHFPGP), an analog of ACTH4–10, and some of its derivatives, in which the N-terminal methionine was modified or substituted with other amino acid residues, was performed. The effect of these peptides on learning of albino rats in tests with positive (food) and negative (pain) reinforcement was studied. In the case of modification of methionine by attachment of the gluconic-acid residue or substitution of methionine with lysine, the nootropic effect of the peptide was retained. The substitution of methionine with tryptophan or serine resulted in a decrease in the nootropic activity. The substitution of methionine with glycine, threonine, or alanine caused a complete loss of the nootropic activity of the peptide. Therefore, the amino acid residue located at position 1 of the heptapeptide analog semax, plays a key role in retaining the nootropic effects of the peptide and determines the degree of their expression.

Keywords

Peptide Glycine Serine Lysine Alanine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MAIK “Nauka/Interperiodica” 2005

Authors and Affiliations

  • N. Yu. Glazova
    • 1
  • E. A. Sebentsova
    • 1
  • N. G. Levitskaya
    • 1
  • L. A. Andreeva
    • 1
  • L. Yu. Alfeeva
    • 1
  • A. A. Kamenskii
    • 2
  • N. F. Myasoedov
    • 1
  1. 1.Institute of Molecular GeneticsRussian Academy of SciencesMoscowRussia
  2. 2.Biological FacultyMoscow State UniversityMoscowRussia

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