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Mechanisms of neurogenic dystrophies induced by activation and deprivation of the sympathetic nervous system

  • Animal Physiology
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Abstract

Entry of abnormal nervous stimuli after sciatic nerve transection proved to affect the functioning of renal mineralocorticoid receptors as a result of inadequate neurotrophic support of this organ. Drug blockade of both neural and humoral transmission of the abnormal stimuli from the injured nerve to the kidney prevented development of trophic disorders as indicated by the status of the renal mineralocorticoid receptor system. At the same time, drug stimulation of the sympathetic nervous system further affected aldosterone reception by this organ. β-Blocker propranolol was shown to exert an antidystrophic effect in the case of local injuries of the neural system and, thus, prevented the development of neurogenic dystrophies.

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  1. Russian Academy of Sciences, ul. Butlerova 5A, 117865, Moscow, Russia

    Yu. A. Akimov & N. S. Kositsyn

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  1. Yu. A. Akimov
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  2. N. S. Kositsyn
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Translated from Izvestiya Akademii Nauk, Seriya Biologicheskaya, No. 2, 2005, pp. 226–231.

Original Russian Text Copyright © 2005 by Akimov, Kositsyn.

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Akimov, Y.A., Kositsyn, N.S. Mechanisms of neurogenic dystrophies induced by activation and deprivation of the sympathetic nervous system. Biol Bull Russ Acad Sci 32, 183–187 (2005). https://doi.org/10.1007/s10525-005-0028-z

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  • DOI: https://doi.org/10.1007/s10525-005-0028-z

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