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Dietary intake of microplastics impairs digestive performance, induces hepatic dysfunction, and shortens lifespan in the annual fish Nothobranchius guentheri

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Abstract

Microplastics (MPs) are ubiquitous in aquatic and terrestrial ecosystem, increasingly becoming a serious concern of human health. Many studies have explored the biological effects of MPs on animal and plant life in recent years. However, information regarding the effects of MPs on aging and lifespan is completely lacking in vertebrate species to date. Here we first confirm the bioavailability of MPs by oral delivery in the annual fish N. guentheri. We then show for the first time that administration of MPs not only shortens the lifespan but also accelerates the development of age-related biomarkers in N. guentheri. We also demonstrate that administration of MPs induces oxidative stress, suppresses antioxidant enzymes, reduces digestive enzymes, and causes hepatic dysfunction. Therefore, we propose that administration of MPs reduces lifespan of N. guentheri via induction of both suppressed antioxidant system and digestive disturbance as well as hepatic damage. Our results also suggest that smaller MPs appear more toxic to digestion, metabolism and growth of animals.

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Acknowledgements

We thank all the participants for their valuable contribution to this study.

Funding

This work was supported by the Ministry of Science and Technology (MOST) of China (2018YFD0900505) and the Natural Science Foundation of China (32073000).

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  1. Kun Xiao and Lili Song have contributed equally to the work.

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  1. Institute of Evolution & Marine Biodiversity and Department of Marine Biology, Ocean University of China, 5 Yushan Road, Qingdao, 266003, China

    Kun Xiao, Lili Song, Yishuai Li, Congjun Li & Shicui Zhang

  2. Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, 266003, China

    Shicui Zhang

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SZ: Funding acquisition, Conceptualization, Data curation, Writing–review & editing; KX: Resources, Methodology, Investigation, Data curation, Writing–original draft; LS: Methodology, Investigation, Software Writing–original draft; YL: Resources; CL: Resources. All authors approved the final version of the manuscript.

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Xiao, K., Song, L., Li, Y. et al. Dietary intake of microplastics impairs digestive performance, induces hepatic dysfunction, and shortens lifespan in the annual fish Nothobranchius guentheri. Biogerontology 24, 207–223 (2023). https://doi.org/10.1007/s10522-022-10007-w

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