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Application of lipidomics strategy to explore aging-related biomarkers and potential anti-aging mechanisms of ginseng

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Abstract

Aging often leads to an increase risk of age-related diseases, and the development of anti-aging drugs have become the trend and focus of the current scientific research. In this experiment, serum samples from healthy people of different ages were analyzed based on clinical lipidomics, and a total of 10 potential biomarkers in middle-aged and youth group, 20 biomarkers in the youth and the elderly group were obtained. Furthermore, dhSph and dhCer involved above may affect the aging process through sphingolipid metabolic pathway. As the first and rate-limiting step of catalyzing de novo sphingolipid pathway, SPT may play a key role in human anti-aging, which is revealed by lipidomics liposome tracer analysis. The potential active components in ginseng on SPT was further verified by molecular docking virtual screening and atomic force microscope. Four ingredients of ginseng may reduce the levels of metabolites dhSph and dhCer by inhibiting the activity of SPT, and play an anti-aging effect by affecting the sphingolipid metabolism pathway.

A clinical trials registration number: ChiCTR1900026836.

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Data availability

All data generated or analysed during this study are included in this published article and its supplementary information files.

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Funding

This work was funded by High-level Innovation Team of Tianjin Talent Development Special Support Program. The National Natural Science Foundation of China (No. 81903933) and the National Natural Science Foundation of China (No. 81873194).

Author information

Author notes

  1. Shenshen Yang, Yaqian Dong and Yuechen Liu contributed equally to this work.

Authors and Affiliations

  1. State Key Laboratory of Component Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, No.10, Poyang Lake Road, Tuanbo New City, Jinghai District, Tianjin, 301617, China

    Shenshen Yang, Yaqian Dong, Yuechen Liu, Xingxu Yan, Guoxiang Jia, Xiaokai Li, Hui Liu & Yubo Li

  2. Department of Kidney Disease and Blood Purification, The Second Hospital of Tianjin Medical University, No. 23 Pingjiang Street, Hexi District, Tianjin, 300211, China

    Guijiang Sun

  3. Department of Endocrinology and Nephrology, PKU Care CNOOC Hospital, Tianjin, China

    Haihua Su

Authors
  1. Shenshen Yang
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  2. Yaqian Dong
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  3. Yuechen Liu
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  4. Xingxu Yan
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  5. Guijiang Sun
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  6. Guoxiang Jia
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  7. Xiaokai Li
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  8. Hui Liu
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  9. Haihua Su
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  10. Yubo Li
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Contributions

HS, YL and SY contributed to the conception of the study; SY, YD, YL and XY performed the experiment; SY, YD, YL performed the data analyses and wrote the manuscript; GS, GJ, XL, Hui Liu helped perform the analysis with constructive discussions.

Corresponding authors

Correspondence to Haihua Su or Yubo Li.

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Conflict of interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and publication of this article.

Ethical approval

This experiment is registered in the China Clinical Trials Registry.

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Informed consent was obtained from all individual participants included in the study. Consent for publication The participant has consented to the submission of the case report to the journal.

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Yang, S., Dong, Y., Liu, Y. et al. Application of lipidomics strategy to explore aging-related biomarkers and potential anti-aging mechanisms of ginseng. Biogerontology 22, 589–602 (2021). https://doi.org/10.1007/s10522-021-09937-8

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  • DOI: https://doi.org/10.1007/s10522-021-09937-8

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