Aging often leads to an increase risk of age-related diseases, and the development of anti-aging drugs have become the trend and focus of the current scientific research. In this experiment, serum samples from healthy people of different ages were analyzed based on clinical lipidomics, and a total of 10 potential biomarkers in middle-aged and youth group, 20 biomarkers in the youth and the elderly group were obtained. Furthermore, dhSph and dhCer involved above may affect the aging process through sphingolipid metabolic pathway. As the first and rate-limiting step of catalyzing de novo sphingolipid pathway, SPT may play a key role in human anti-aging, which is revealed by lipidomics liposome tracer analysis. The potential active components in ginseng on SPT was further verified by molecular docking virtual screening and atomic force microscope. Four ingredients of ginseng may reduce the levels of metabolites dhSph and dhCer by inhibiting the activity of SPT, and play an anti-aging effect by affecting the sphingolipid metabolism pathway.
A clinical trials registration number: ChiCTR1900026836.
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This work was funded by High-level Innovation Team of Tianjin Talent Development Special Support Program. The National Natural Science Foundation of China (No. 81903933) and the National Natural Science Foundation of China (No. 81873194).
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The authors declared no potential conflicts of interest with respect to the research, authorship, and publication of this article.
This experiment is registered in the China Clinical Trials Registry.
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Yang, S., Dong, Y., Liu, Y. et al. Application of lipidomics strategy to explore aging-related biomarkers and potential anti-aging mechanisms of ginseng. Biogerontology (2021). https://doi.org/10.1007/s10522-021-09937-8
- Sphingolipid metabolism