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d-Galactose-induced accelerated aging model: an overview

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Abstract

To facilitate the process of aging healthily and prevent age-related health problems, efforts to properly understand aging mechanisms and develop effective and affordable anti-aging interventions are deemed necessary. Systemic administration of d-galactose has been established to artificially induce senescence in vitro and in vivo as well as for anti-aging therapeutic interventions studies. The aim of this article is to comprehensively discuss the use of d-galactose to generate a model of accelerated aging and its possible underlying mechanisms involved in different tissues/organs.

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Acknowledgements

The authors would like to acknowledge School of Medical Sciences, Universiti Sains Malaysia and short-term research grant of Universiti Sains Malaysia (304/PPSP/6315093).

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Azman, K.F., Zakaria, R. d-Galactose-induced accelerated aging model: an overview. Biogerontology 20, 763–782 (2019). https://doi.org/10.1007/s10522-019-09837-y

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