High perceived stress in women is linked to oxidation, inflammation and immunosenescence
Chronic stress situations lead to an impairment of immune response and higher oxidative and inflammatory stress, which are important underlying mechanisms of the ageing process. However, given that the physiological stress response depends on the subjective appraisal of a given stressor, the aim of the study was to investigate the effect that different degrees of perceived stress have, regardless of their type, on immune functions, oxidative and inflammatory stress and ageing rate of women (30–50 years old). For that purpose, a group of 49 women was classified, according to their scores obtained in the perceived stress scale (PSS), into low (n = 23), moderate (n = 14) and high (n = 12) degree of perceived stress. The immune functions studied were: neutrophil and lymphocyte chemotaxis, neutrophil phagocytic capacity, natural killer activity, lymphoproliferation and LPS-stimulated cytokine release. Basal cytokine release was studied as an inflammatory stress marker. Antioxidant (superoxide dismutase, glutathione peroxidase and reductase activities, and reduced glutathione) and oxidant compounds (oxidized glutathione and malondialdehyde) were also investigated in whole blood as markers of oxidative stress. The results show that, in general, women with a moderate or high degree of perceived stress have a worse immune functionality and higher oxidative and inflammatory stress compared to women with low stress perception. In addition, a positive correlation was found between PSS scores and the biological age of each woman (P ≤ 0.001). In conclusion, high levels of perceived stress in women are associated with a higher oxidative and inflammatory stress and immunosenescence, which seem to accelerate their ageing rate.
KeywordsStress perception Immunosenescence Oxidative stress Inflammatory stress Biological age
This work was supported by Grants of FIS (PI15/01787) from the ISCIII-FEDER of the European Union and of UCM-Research Group.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- Cohen S, Kessler RC, Gordon LU (1997) Measuring stress: a guide for health and social scientists. Oxford University Press, NewYorkGoogle Scholar
- Forlenza MJ, Miller GE (2006) Increased serum levels of 8-hydroxy-20-deoxyguanosine in clinical depression. Psychosom Med 68:1–7. https://doi.org/10.1097/01.psy.0000195780.37277.2a CrossRefPubMedGoogle Scholar
- Maes M, Song C, Lin A, De Jongh R, Van Gastel A, Kenis G, Bosmans E, De Meester I, Benoy I, Neels H, Demedts P, Janca A, Scharpe S, Smith RS (1998) The effects of psychological stress on humans: increased production of pro-inflammatory cytokines and th1-like response in stress-induced anxiety. Cytokine 10:313–318. https://doi.org/10.1006/cyto.1997.0290 CrossRefPubMedGoogle Scholar
- Salvioli S, Monti D, Lanzarini C, Conte M, Pirazzini C, Bacalini MG, Garagnani P, Giuliani C, Fontanesi E, Ostan R, Bucci L, Sevini F, Yani SL, Barbieri A, Lomartire L, Borelli V, Vianello D, Bellavista E, Martucci M, Cevenini E, Pini E, Scurti M, Biondi F, Santoro A, Capri M, Franceschi C (2013) Immune system, cell senescence, aging and longevity–inflamm-aging reappraised. Curr Pharm Des 19(9):1675–1679. https://doi.org/10.2174/1381612811319090015 CrossRefPubMedGoogle Scholar
- Vida C, Martínez de Toda I, Garrido A, Carro E, Molina JA, De la Fuente M (2017b) Impairment of several immune functions and redox state in blood cells of Alzheimer’s disease patients. Relevant role of neutrophils in oxidative stress. Front Immunol 8:1974. https://doi.org/10.3389/fimmu.2017.01974 CrossRefPubMedGoogle Scholar