Ageing with elegans: a research proposal to map healthspan pathways
- 1.1k Downloads
Human longevity continues to increase world-wide, often accompanied by decreasing birth rates. As a larger fraction of the population thus gets older, the number of people suffering from disease or disability increases dramatically, presenting a major societal challenge. Healthy ageing has therefore been selected by EU policy makers as an important priority (http://www.healthyageing.eu/european-policies-and-initiatives); it benefits not only the elderly but also their direct environment and broader society, as well as the economy. The theme of healthy ageing figures prominently in the Horizon 2020 programme (https://ec.europa.eu/programmes/horizon2020/en/h2020-section/health-demographic-change-and-wellbeing), which has launched several research and innovation actions (RIA), like “Understanding health, ageing and disease: determinants, risk factors and pathways” in the work programme on “Personalising healthcare” (https://ec.europa.eu/research/participants/portal/desktop/en/opportunities/h2020/topics/693-phc-01-2014.html). Here we present our research proposal entitled “ageing with elegans” (AwE) (http://www.h2020awe.eu/), funded by this RIA, which aims for better understanding of the factors causing health and disease in ageing, and to develop evidence-based prevention, diagnostic, therapeutic and other strategies. The aim of this article, authored by the principal investigators of the 17 collaborating teams, is to describe briefly the rationale, aims, strategies and work packages of AwE for the purposes of sharing our ideas and plans with the biogerontological community in order to invite scientific feedback, suggestions, and criticism.
KeywordsHealthspan Longevity Nutraceuticals Medicinal plants Natural products Caenorhabditis elegans
We would like to thank Dr. Iesel Van der Plancken, Dr. Daniel Ramón, and Dr. Steven Van Vooren for critical comments on the AwE proposal, and Dr. Geert Depuydt and Brecht Wouters (KU Leuven) for help with finalising the manuscript. This project has received funding from the European Union’s Horizon 2020 research and innovation programme under Grant agreement No 633589. This publication reflects only the authors’ views and the Commission is not responsible for any use that may be made of the information it contains.
- Bitto, A., A. M. Wang, C. F. Bennett and M. Kaeberlein (2015) Biochemical genetic pathways that modulate aging in multiple species. Cold Spring Harb Perspect Med 5: a025114Google Scholar
- Churgin MA, Jung S, Yu CC, Chen X, Raizen DM, Fang-Yen C (2016) High-throughput longitudinal imaging of healthspan and longevity in Caenorhabditis elegans (unpublished manuscript)Google Scholar
- Fuellen G, Schofield P, Flatt T, Schulz R-J, Boege F, Kraft K, Simm A (2015) Living long and well: prospects for a personalized approach to the medicine of ageing. GerontologyGoogle Scholar
- Juhasz Gabriella, Hullam Gabor, Eszlaria Nora, Gonda Xenia, Antal Peter, Anderson Ian Muir, Hökfeltf Tomas G M, William Deakin JF, Bagdy Gyorgy (2014) Brain galanin system genes interact with life stresses in depression-related phenotypes. Proc Natl Acad Sci 111(16):E1666–E1673CrossRefPubMedPubMedCentralGoogle Scholar
- Seals DR, Justice JN, LaRocca TJ (2015) Physiological geroscience: targeting function to increase healthspan and achieve optimal longevity. J Physiol (Lond.) 11:1–24Google Scholar
- Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiller E, Hergueta T, Baker R, Dunbar GC (1998) The mini-international neuropsychiatric interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatr 59(Suppl 20):22–33; quiz 34–57Google Scholar