The death spiral: predicting death in Drosophila cohorts
Drosophila research has identified a new feature of aging that has been called the death spiral. The death spiral is a period prior to death during which there is a decline in life-history characters, such as fecundity, as well as physiological characters. First, we review the data from the Drosophila and medfly literature that suggest the existence of death spirals. Second, we re-analyze five cases with such data from four laboratories using a generalized statistical framework, a re-analysis that strengthens the case for the salience of the death spiral phenomenon. Third, we raise the issue whether death spirals need to be taken into account in the analysis of functional characters over age, in aging research with model species as well as human data.
KeywordsDrosophila melanogaster Aging Fecundity Virility Demography Disability
- Beard RE (1959) Note on some mathematical mortality models. In: Wolstenholme GEW, O’Connor M (eds) The lifespan of animals, Ciba Foundation Colloquium on Ageing. Little, Brown, Boston, pp 302–311Google Scholar
- Belsky DW, Caspic A, Houts R, Cohen HJ, Corcoran DL, Danese A, Harrington H, Israel S, Levine ME, Schaefer JD, Sugden K, Williams B, Yashin AI, Poulton R, Moffitt TE (2015) Quantification of biological aging in young adults. Proc Natl Acad Sci USA 112:E4104–E4110CrossRefPubMedPubMedCentralGoogle Scholar
- Comfort A (1979) Ageing: the biology of senescence, 3rd edn. Churchill Livingstone, EdinburghGoogle Scholar
- Gareth J, Witten D, Hastie T, Tibshirani R (2013) An introduction to statistical learning with applications in R. Spinger, New YorkGoogle Scholar
- Greenwood M, Irwin JO (1939) Biostatistics of senility. Hum Biol 11:1–23Google Scholar