Methanol extracts from the resurrection plant Haberlea rhodopensis ameliorate cellular vitality in chronologically ageing Saccharomyces cerevisiae cells

Georgieva, Milena; Moyankova, Daniela; Djilianov, Dimitar; Uzunova, Katya; Miloshev, George

doi:10.1007/s10522-015-9566-z

Research Article
Published: 11 March 2015

Methanol extracts from the resurrection plant Haberlea rhodopensis ameliorate cellular vitality in chronologically ageing Saccharomyces cerevisiae cells

Milena Georgieva¹,
Daniela Moyankova²,
Dimitar Djilianov²,
Katya Uzunova¹ &
George Miloshev¹

Biogerontology volume 16, pages 461–472 (2015)Cite this article

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Abstract

Bioactive substances that are found in many natural plant extracts are very important for the cosmetics, pharmaceutical industry and biotechnology. Especially interesting for these industries are the substances that possess cell revitalizing and anti-ageing properties. The endemic plant Haberlea rhodopensis is known for its ability to withstand drought and to revitalize when returned to optimal conditions after a long time in desiccation. It is a mere fact that this plant not only can completely resurrect from a dried state but is also able to bring back the natural biochemical compositions of its cells. As a result H. rhodopensis offers a wide field for investigation of the exact mechanisms of the revitalization process as well as broadens the search for unique bioactive chemical substances in its cells. Here, by using the yeast Saccharomyces cerevisiae as a model we have demonstrated that methanol extracts from the plant H. rhodopensis hold specific properties to revitalize and ameliorate cellular growth as well as to balance intracellular metabolic states. Our results add valuable knowledge on the effects of natural compounds on ageing and reinforce the idea of using yeast as a model organism in the development of rapid tests for studying the efficacy of different bioactive substances.

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Authors and Affiliations

Laboratory of Yeast Molecular Genetics, Institute of Molecular Biology “Roumen Tzanev”, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria
Milena Georgieva, Katya Uzunova & George Miloshev
Abiotic Stress, Agrobioinstitute, 8 Dragan Tsankov Blvd., 1164, Sofia, Bulgaria
Daniela Moyankova & Dimitar Djilianov

Authors

Milena Georgieva
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Daniela Moyankova
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Dimitar Djilianov
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Katya Uzunova
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George Miloshev
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Correspondence to George Miloshev.

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Georgieva, M., Moyankova, D., Djilianov, D. et al. Methanol extracts from the resurrection plant Haberlea rhodopensis ameliorate cellular vitality in chronologically ageing Saccharomyces cerevisiae cells. Biogerontology 16, 461–472 (2015). https://doi.org/10.1007/s10522-015-9566-z

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Received: 21 November 2014
Accepted: 04 March 2015
Published: 11 March 2015
Issue Date: August 2015
DOI: https://doi.org/10.1007/s10522-015-9566-z

Keywords

Resurrection plant
Haberlea rhodopensis
Saccharomyces cerevisiae
Ageing
Cellular vitality
Metabolism
Model organism