Abstract
Nothobranchius is a genus of annual fish broadly distributed in South-Eastern Africa and found into temporary ponds generated during the rain seasons and their lifespan is limited by the duration of their habitats. Here we compared two Nothobranchius species from radically different environments: N. furzeri and N. korthausae. We found a large difference in life expectancy (29- against 71-weeks of median life span, 40- against 80-weeks of maximum lifespan, respectively), which correlates with a diverse timing in the onset of several age dependent processes: our data show that N. korthause longer lifespan is associated to retarded onset of age-dependent liver-neoplasia and slower down-regulation of collagen 1 alpha 2 (COL1A2) expression in the skin. On the other hand, the expression of cyclin B1 (CCNB1) in the brain was strongly age-regulated, but with similar profiles in N. furzeri and N. korthausae. In conclusion, our data suggest that the different ageing rate of two species of the same genus could be used as novel tool to investigate and better understand the genetic bases of some general mechanism leading to the complex ageing process, providing a strategy to unravel some of the genetic mechanisms regulating longevity and age-associate pathologies including neoplasias.
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References
Baumgart M, Groth M, Priebe S, Appelt J, Guthke R, Platzer M, Cellerino A (2012) Age-dependent regulation of tumor-related microRNAs in the brain of the annual fish Nothobranchius furzeri. Mech Ageing Dev 133:226–233. doi:10.1016/j.mad.2012.03.015
Cooper EL, Zapata A, Garcia Barrutia M, Ramirez JA (1983) Aging changes in lymphopoietic and myelopoietic organs of the annual cyprinodont fish Nothobranchius guentheri. Exp Gerontol 18:29–38
Di Cicco E, Tozzini ET, Rossi G, Cellerino A (2011) The short-lived annual fish Nothobranchius furzeri shows a typical teleost aging process reinforced by high incidence of age-dependent neoplasias. Exp Gerontol 46:249–256. doi:10.1016/j.exger.2010.10.011
Genade T, Lang DM (2013) Resveratrol extends lifespan and preserves glia but not neurons of the Nothobranchius guentheri optic tectum. Exp Gerontol 48:202–212. doi:10.1016/j.exger.2012.11.013
Genade T, Benedetti M, Terzibasi E, Roncaglia P, Valenzano DR, Cattaneo A, Cellerino A (2005) Annual fishes of the genus Nothobranchius as a model system for aging research. Aging Cell 4:223–233
Hartmann N et al (2009) Telomeres shorten while tert expression increases during ageing of the short-lived fish Nothobranchius furzeri. Mech Ageing Dev 130:290–296. doi:10.1016/j.mad.2009.01.003
Hartmann N et al (2011) Mitochondrial DNA copy number and function decrease with age in the short-lived fish Nothobranchius furzeri. Aging Cell 10:824–831. doi:10.1111/j.1474-9726.2011.00723.x
Herrera M, Jagadeeswaran P (2004) Annual fish as a genetic model for aging. J Gerontol A Biol Sci Med Sci 59:101–107
Hsu CY, Chiu YC (2009) Ambient temperature influences aging in an annual fish (Nothobranchius rachovii). Aging Cell 8:726–737. doi:10.1111/j.1474-9726.2009.00525.x
Hsu CY, Chiu YC, Hsu WL, Chan YP (2008) Age-related markers assayed at different developmental stages of the annual fish Nothobranchius rachovii. J Gerontol A Biol Sci Med Sci 63:1267–1276
Kirschner J et al (2012) Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri- a new vertebrate model for age research. Aging Cell 11:252–261. doi:10.1111/j.1474-9726.2011.00780.x
Liu C, Wang X, Feng W, Li G, Su F, Zhang S (2012) Differential expression of aging biomarkers at different life stages of the annual fish Nothobranchius guentheri. Biogerontology 13:501–510. doi:10.1007/s10522-012-9395-2
Lucas-Sanchez A, Almaida-Pagan PF, Madrid JA, de Costa J, Mendiola P (2011) Age-related changes in fatty acid profile and locomotor activity rhythms in Nothobranchius korthausae. Exp Gerontol 46:970–978. doi:10.1016/j.exger.2011.08.009
Lucas-Sanchez A, Almaida-Pagan PF, Martinez-Nicolas A, Madrid JA, Mendiola P, de Costa J (2013) Rest-activity circadian rhythms in aged Nothobranchius korthausae. The effects of melatonin. Exp Gerontol 48:507–516. doi:10.1016/j.exger.2013.02.026
Lucas-Sanchez A, Almaida-Pagan PF, Tocher DR, Mendiola P, de Costa J (2014) Age-related changes in mitochondrial membrane composition of Nothobranchius rachovii. J Gerontol A Biol Sci Med Sci 69:142–151. doi:10.1093/gerona/glt066
Petzold A et al (2013) The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levels. BMC Genomics 14:185. doi:10.1186/1471-2164-14-185
Reichwald K et al (2009) High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research. Genome Biol 10:R16. doi:10.1186/gb-2009-10-2-r16
Terzibasi E, Valenzano DR, Benedetti M, Roncaglia P, Cattaneo A, Domenici L, Cellerino A (2008) Large differences in aging phenotype between strains of the short-lived annual fish Nothobranchius furzeri. PLoS ONE 3:e3866. doi:10.1371/journal.pone.0003866
Tozzini TE, Baumgart M, Battistoni G, Cellerino A (2012) Adult neurogenesis in the short-lived teleost Nothobranchius furzeri: localization of neurogenic niches, molecular characterization and effects of aging. Aging Cell 11:241–251. doi:10.1111/j.1474-9726.2011.00781.x
Tozzini ET et al (2013) Parallel evolution of senescence in annual fishes in response to extrinsic mortality. BMC Evol Biol 13:77. doi:10.1186/1471-2148-13-77
Valdesalici S, Cellerino A (2003) Extremely short lifespan in the annual fish Nothobranchius furzeri. Proc R Soc Lond B Biol Sci 270(Suppl 2):S189–S191
Valenzano DR, Terzibasi E, Cattaneo A, Domenici L, Cellerino A (2006) Temperature affects longevity and age-related locomotor and cognitive decay in the short-lived fish Nothobranchius furzeri. Aging Cell 5:275–278. doi:10.1111/j.1474-9726.2006.00212.x
Valenzano DR et al (2009) Mapping loci associated with tail color and sex determination in the short-lived fish Nothobranchius furzeri. Genetics 183:1385–1395. doi:10.1534/genetics.109.108670
Wildekamp RH (2004) A World of Killies—atlas of the oviparous cyprinodontiform fishes of the world. The American Killifish Association, Elyria, OH
Acknowledgements
We wish to thank Sabine Matz and Julia Bluhm for technical assistance; Alexander Dorn for providing us the eggs of N. korthausae; the AIRC Foundation (Grant MFAG-11511 to E.T.T.), the DFG Foundation (Grant CE 46/6-1 to A.C.) and the German Ministry for Education and Research (JenAge; BMBF, support code: 0315581A) for the financial support. The animal work was approved by the State of Thuringia (Auth. Nr. 03-001/09).
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Baumgart, M., Di Cicco, E., Rossi, G. et al. Comparison of captive lifespan, age-associated liver neoplasias and age-dependent gene expression between two annual fish species: Nothobranchius furzeri and Nothobranchius korthause . Biogerontology 16, 63–69 (2015). https://doi.org/10.1007/s10522-014-9535-y
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DOI: https://doi.org/10.1007/s10522-014-9535-y