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Gadd45 expression correlates with age dependent neurodegeneration in Drosophila melanogaster

Biogerontology volume 16, pages 53–61 (2015)Cite this article

Abstract

The neurodegeneration is one of the features of aging and age-related disorders. Yet, only several antiaging interventions are known to affect the processes of neurodegeneration. Here we show that overexpression of the pro-longevity gene D-GADD45 in Drosophila neurons leads to a postponed manifestation of histological and ultrastructural features of age-dependent neurodegeneration, such as decrease in the packing density of neurons, increasing the degree of neuron cytoplasmic vacuolization, and morphological defects of mitochondrial cristae. Thus, the previously observed (Plyusnina, Biogerontology 12: 211–226, 2011) life extending effect of D-GADD45 overexpression in the nervous system is associated with delayed neurodegeneration.

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Acknowledgments

The study was supported by the projects of UrB RAS No. 12-C-4-1019 and SB RAS No. 81, 82, Grant of RFBR N 14-04-01596.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology Siberian Branch of RAMS, Novosibirsk, Russia

    Natalia Bgatova

  2. Institute of Molecular and Cellular Biology, Siberian Branch of RAS, 8/2, Ac. Lavrentieva Ave, 630090, Novosibirsk, Russia

    Tatiana Dubatolova & Leonid Omelyanchuk

  3. Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia

    Ekaterina Plyusnina, Mikhail Shaposhnikov & Alexey Moskalev

  4. Syktyvkar State University, Syktyvkar, Russia

    Ekaterina Plyusnina, Mikhail Shaposhnikov & Alexey Moskalev

  5. Moscow Institute of Physics and Technology (State University), Dolgoprudny, Russia

    Alexey Moskalev

Authors
  1. Natalia Bgatova
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  2. Tatiana Dubatolova
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  3. Leonid Omelyanchuk
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  4. Ekaterina Plyusnina
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  5. Mikhail Shaposhnikov
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  6. Alexey Moskalev
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Corresponding author

Correspondence to Leonid Omelyanchuk.

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Bgatova, N., Dubatolova, T., Omelyanchuk, L. et al. Gadd45 expression correlates with age dependent neurodegeneration in Drosophila melanogaster . Biogerontology 16, 53–61 (2015). https://doi.org/10.1007/s10522-014-9533-0

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  • DOI: https://doi.org/10.1007/s10522-014-9533-0

Keywords

  • Gadd45
  • Neurodegeneration
  • Drosophila model
  • Aging
  • Brain histology
  • Nervous system ultrastructure