, Volume 13, Issue 3, pp 215–235 | Cite as

Hormesis: why it is important to biogerontologists

  • Edward J. CalabreseEmail author
  • Ivo Iavicoli
  • Vittorio Calabrese
Review Article


This paper offers a broad assessment of the hormetic dose response and its relevance to biogerontology. The paper provides detailed background information on the historical foundations of hormesis, its quantitative features, mechanistic foundations, as well as how the hormesis concept could be further applied in the development of new therapeutic advances in the treatment of age-related diseases. The concept of hormesis has direct application to biogerontology not only affecting the quality of the aging process but also experimental attempts to extend longevity.


Hormesis Hormetin Biphasic U-shaped J-shaped Adaptive response 



Effort sponsored by the Air Force Office of Scientific Research, Air Force Material Command, USAF, under grant number FA9550-07-1-0248. The U.S. Government is authorized to reproduce and distribute for governmental purposes notwithstanding any copyright notation thereon. The views and conclusions contained herein are those of the authors and should not be interpreted as necessarily representing the official policies or endorsement, either expressed or implied, of the Air Force Office of Scientific Research or the U.S. Government. The sponsors had no role in study design, collection, analysis and interpretation of data, writing of the report and decision to submit the manuscript for publication.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Edward J. Calabrese
    • 1
    Email author
  • Ivo Iavicoli
    • 2
  • Vittorio Calabrese
    • 3
  1. 1.Department of Public Health, Environmental Health SciencesUniversity of MassachusettsAmherstUSA
  2. 2.Istituto di Medicina del LavoroUniversitá Cattolica del Sacro CuoreRomaItaly
  3. 3.Department of ChemistryUniversity of CataniaCataniaItaly

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