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Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: relationship with neuro-degeneration

Biogerontology volume 12, pages 451–454 (2011)Cite this article

Abstract

Neurodegenerative processes associated with Alzheimer’s disease (AD) are accompanied by reactive astrogliosis and microglia activation and a role for chronic inflammation in the brain degeneration of these patients has been suggested. Moreover impaired immune functions in AD brains might also influence the disease’s progression. Therefore, it is of interest to further characterized inflammatory molecules in the peripheral blood of patients with AD and its relationship with cognitive decline. A complex picture emerged in this pilot study and IL-8, IFN-gamma, MCP-1 and VEGF levels were increased in AD. Levels of P-selectin and L-selectin were decreased in AD and lowest in AD patients with highest cognitive decline. Our findings suggest that these molecules may induce alterations of endothelial regulation and influence neurodegenerative processes of AD.

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Affiliations

  1. Department of Human Morphology and Biomedical Sciences “Città Studi”, Clinical Pathology Unit, Medical Faculty, University of Milan, Via Luigi MAngiagalli 31, 20133, Milan, Italy

    Massimiliano M. Corsi, Giada Dogliotti & Emanuela Galliera

  2. IRCCS Policlinico San Donato, San Donato, Italy

    Massimiliano M. Corsi

  3. Department of Experimental Pathology, Immunology Unit, Medical Faculty, University of Bologna, Bologna, Italy

    Federico Licastro & Elisa Porcellini

  4. Randox Laboratories, Crumlin, Co. Antrim, Northern Ireland, UK

    John L. Lamont, Paul J. Innocenzi & Stephen P. Fitzgerald

Authors
  1. Massimiliano M. Corsi
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  2. Federico Licastro
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  3. Elisa Porcellini
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  4. Giada Dogliotti
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  5. Emanuela Galliera
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  6. John L. Lamont
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  7. Paul J. Innocenzi
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  8. Stephen P. Fitzgerald
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Correspondence to Massimiliano M. Corsi.

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Corsi, M.M., Licastro, F., Porcellini, E. et al. Reduced plasma levels of P-selectin and L-selectin in a pilot study from Alzheimer disease: relationship with neuro-degeneration. Biogerontology 12, 451–454 (2011). https://doi.org/10.1007/s10522-011-9335-6

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  • DOI: https://doi.org/10.1007/s10522-011-9335-6

Keywords

  • P-selectin
  • L-selectin
  • Alzheimer’s disease diagnosis and prognosis
  • Slow cognitive decline
  • Fast cognitive decline