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Biogerontology in Finland

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Abstract

This paper describes current biogerontology research in Finland especially in the universities with professorships in gerontology/geriatrics. If biogerontology is broadly taken to include all research in basic mechanisms of normal ageing as well as age-related diseases, the most prevalent current topics include basic research in genetics, mitochondrial function, musculoskeletal physiology, neurodegenerative and vascular diseases. The research activity of each institute and their international collaboration is briefly described with examples focused on recent publications in the field of biogerontology.

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References

  • Cruz-Jentoft AJ, Franco A, Sommer P, Baeyens JP, Jankowska E, Maggi A, Ponikowski P, Rys A, Szczerbinska K, Michel JP, Milewicz A (2009) Silver paper: the future of health promotion and preventive actions, basic research, and clinical aspects of age-related disease—a report of the European summit on age-related disease. Aging Clin Exp Res 21(6):376–385

    PubMed  Google Scholar 

  • Erkinjuntti T, Gauthier S (2009) The concept of vascular cognitive impairment. Front Neurol Neurosci 24:79–85

    Article  PubMed  Google Scholar 

  • Franceschi C, Bezrukov V, Blanché H, Bolund L, Christensen K, de Benedictis G, Deiana L, Gonos E, Hervonen A, Yang H, Jeune B, Kirkwood TB, Kristensen P, Leon A, Pelicci PG, Peltonen L, Poulain M, Rea IM, Remacle J, Robine JM, Schreiber S, Sikora E, Slagboom PE, Spazzafumo L, Stazi MA, Toussaint O, Vaupel JW (2007) Genetics of healthy aging in Europe: the EU-integrated project GEHA (GEnetics of Healthy Aging). Ann NY Acad Sci 1100:21–45

    Article  PubMed  CAS  Google Scholar 

  • Fyhrquist F, Tiitu A, Saijonmaa O, Forsblom C, Groop PH, FinnDiane Study Group (2010) Telomere length and progression of diabetic nephropathy in patients with type 1 diabetes. J Intern Med 267(3):278–286

    Article  PubMed  CAS  Google Scholar 

  • Hakonen AH, Heiskanen S, Juvonen V, Lappalainen I, Luoma PT, Rantamaki M, Goethem GV, Lofgren A, Hackman P, Paetau A, Kaakkola S, Majamaa K, Varilo T, Udd B, Kaariainen H, Bindoff LA, Suomalainen A (2005) Mitohondrial DNA polymerase W748S mutation: a common cause of autosomal recessive ataxia with ancient European origin. Am J Hum Genet 77(3):430–441

    Article  PubMed  CAS  Google Scholar 

  • Hamerman D (2010) Can biogerontologists and geriatricians unite to apply aging science to health care in the decade ahead? J Gerontol A Biol Sci Med Sci 65(11):1193–1197

    PubMed  Google Scholar 

  • Heikkilä HM, Trosien J, Metso J, Jauhiainen M, Pentikäinen MO, Kovanen PT, Lindstedt KA (2010) Mast cells promote atherosclerosis by inducing both an atherogenic lipid profile and vascular inflammation. J Cell Biochem 109(3):615–623

    PubMed  Google Scholar 

  • Hellström-Lindahl E, Viitanen M, Marutle A (2009) Comparison of Abeta levels in the brain of familial and sporadic Alzheimer’s disease. Neurochem Int 55(4):243–252

    Article  PubMed  Google Scholar 

  • Hervonen A, Koistinaho J, Alho H, Helen P, Santer RM, Rapoport SI (1986) Age related heterogeneity of lipopigments in human sympathetic ganglia. Mech Ageing Dev 35(6):17–29

    Article  PubMed  CAS  Google Scholar 

  • Hyvärinen AK, Pohjoismäki JL, Holt IJ, Jacobs HT (2010) Overexpression of MTERFD1 or MTERFD3 impairs the completion of mitochondrial DNA replication. Mol Biol Rep. doi:10.1007/s11033-010-0233-9

  • Jaatinen P, Riikonen J, Riihioja P, Kajander O, Hervonen A (2003) Interaction of aging and intermittent ethanol exposure on brain cytochrome c oxidase activity levels. Alcohol 29(2):91–100

    Article  PubMed  CAS  Google Scholar 

  • Jylhävä J, Eklund C, Jylhä M, Hervonen A, Hurme M (2010) Expression profiling of immune-associated genes in peripheral blood mononuclear cells reveals baseline differences in co-stimulatory signalling between nonagenarians and younger controls: the vitality 90+ study. Biogerontology 11(6):671–677

    Article  PubMed  Google Scholar 

  • Kanninen K, Heikkinen R, Malm T, Rolova T, Kuhmonen S, Leinonen H, Ylä-Herttuala S, Tanila H, Levonen AL, Koistinaho M, Koistinaho J (2009) Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer’s disease. Proc Natl Acad Sci USA 106(38):16505–16510

    Article  PubMed  CAS  Google Scholar 

  • Knuuti J, Tuunanen H (2010) Metabolic imaging in myocardial ischemia and heart failure. Q J Nucl Med Mol Imaging 54(2):168–176

    PubMed  CAS  Google Scholar 

  • Korhonen MT, Cristea A, Alén M, Häkkinen K, Sipilä S, Mero A, Viitasalo JT, Larsson L, Suominen H (2006) Aging, muscle fiber type, and contractile function in sprint-trained athletes. J Appl Physiol 101(3):906–917

    Article  PubMed  CAS  Google Scholar 

  • Korhonen P, van Groen T, Thornell A, Kyrylenko S, Soininen ML, Ojala J, Peltomaa E, Tanila H, Salminen A, Mandelkow EM, Soininen H (2010) Characterization of a novel transgenic rat carrying human tau with mutation P301L. Neurobiol Aging. doi:10.1016/j.neurobiolaging.2009.12.022

  • Kovanen V, Suominen H, Risteli J, Risteli L (1988) Type IV collagen and laminin in slow and fast skeletal muscle in rats—effects of age and life-time endurance training. Coll Relat Res 8(2):145–153

    PubMed  CAS  Google Scholar 

  • Krüger J, Hinttala R, Majamaa K, Remes AM (2010) Mitochondrial DNA haplogroups in early-onset Alzheimer’s disease and frontotemporal lobar degeneration. Mol Neurodegener 5(6):8

    Article  PubMed  Google Scholar 

  • Lee MS, Lyoo CH, Ryu YH, Lim HS, Nam CM, Kim HS, Rinne JO (2010) The effect of age on motor deficits and cerebral glucose metabolism of Parkinson’s disease. Acta Neurol Scand. doi:10.1111/j.1600-0404.2010.01446.x

  • Lovestone S, Francis P, Kloszewska I, Mecocci P, Simmons A, Soininen H, Spenger C, Tsolaki M, Vellas B, Wahlund LO, Ward M, AddNeuroMed Consortium (2009) AddNeuroMed–the European collaboration for the discovery of novel biomarkers for Alzheimer’s disease. Ann N Y Acad Sci 1180(10):36–46

    Article  PubMed  CAS  Google Scholar 

  • Luoma P, Melberg A, Rinne JO, Kaukonen JA, Nupponen NN, Chalmers RM, Oldfors A, Rautakorpi I, Peltonen L, Majamaa K, Somer H, Suomalainen A (2004) Parkinsonism, premature menopause, and mitochondrial DNA polymerase gamma mutations: clinical and molecular genetic study. Lancet 364(9437):875–882

    Article  PubMed  CAS  Google Scholar 

  • Mäkinen PI, Lappalainen JP, Heinonen SE, Leppänen P, Lähteenvuo MT, Aarnio JV, Heikkilä J, Turunen MP, Ylä-Herttuala S (2010) Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors. Cardiovasc Res 88(3):530–538

    Article  PubMed  Google Scholar 

  • Malm T, Koistinaho M, Muona A, Magga J, Koistinaho J (2010) The role and therapeutic potential of monocytic cells in Alzheimer’s disease. Glia 58(8):889–900

    PubMed  Google Scholar 

  • Mikkola T, Sipilä S, Rantanen T, Sievänen H, Suominen H, Kaprio J, Koskenvuo M, Kauppinen M, Heinonen A (2008) Genetic and environmental influence on structural strength of weight-bearing and non-weight-bearing bone: a twin study. J Bone Min Res 23(4):492–498

    Article  Google Scholar 

  • Mykkänen K, Junna M, Amberla K, Bronge L, Kääriäinen H, Pöyhönen M, Kalimo H, Viitanen M (2009) Different clinical phenotypes in monozygotic CADASIL twins with a novel NOTCH3 mutation. Stroke 40(6):2215–2218

    Article  PubMed  Google Scholar 

  • Niemi AK, Moilanen JS, Tanaka M, Hervonen A, Hurme M, Lehtimäki T, Arai Y, Hirose N, Majamaa K (2005) A combination of three common inherited mitochondrial DNA polymorphisms promotes longevity in Finnish and Japanese subjects. Eur J Hum Genet 13(2):166–170

    Article  PubMed  CAS  Google Scholar 

  • Pöllänen E, Fey V, Törmäkangas T, Ronkainen P, Taaffe D, Takala T, Koskinen S, Cheng S, Puolakka J, Kujala U, Suominen H, Sipilä S, Kovanen V (2010) Power training and postmenopausal hormone therapy affect transcriptional control of specific co-regulated gene clusters in skeletal muscle. Age 32(3):347–363

    Article  PubMed  Google Scholar 

  • Ronkainen PH, Kovanen V, Alén M, Pöllänen E, Palonen EM, Ankarberg-Lindgren C, Hämäläinen E, Turpeinen U, Kujala UM, Puolakka J, Kaprio J, Sipilä S (2009) Postmenopausal hormone replacement therapy modifies skeletal muscle composition and function: a study with monozygotic twin pairs. J Appl Physiol 107(1):25–33

    Article  PubMed  CAS  Google Scholar 

  • Ronkainen P, Pöllänen E, Alén M, Pitkänen R, Puolakka J, Kujala UM, Kaprio J, Sipilä S, Kovanen V (2010) Global gene expression profiles in skeletal muscle of monozygotic female twins discordant for hormone replacement therapy. Aging Cell 9(6):1098–1110

    Article  PubMed  CAS  Google Scholar 

  • Rutanen J, Yaluri N, Modi S, Pihlajamäki J, Vänttinen M, Itkonen P, Kainulainen S, Yamamoto H, Lagouge M, Sinclair DA, Elliott P, Westphal C, Auwerx J, Laakso M (2010) SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity. Diabetes 59(4):829–835

    Article  PubMed  CAS  Google Scholar 

  • Sarajärvi T, Helisalmi S, Antikainen L, Mäkinen P, Koivisto AM, Herukka SK,Haapasalo A, Soininen H, Hiltunen M (2010) Association study of 21 potential Alzheimer’s disease risk genes among finnish population. J Alzheimers Dis 21(3):763–767

    PubMed  Google Scholar 

  • Serpi R, Tolonen AM, Huusko J, Rysä J, Tenhunen O, Ylä-Herttuala S, Ruskoaho H (2010) Vascular endothelial growth factor-B gene transfer prevents angiotensin II-induced diastolic dysfunction via proliferation and capillary dilatation in rats. Cardiovasc Res. doi:10.1093/cvr/cvq267

  • Sierra F (2009) Biology of aging summit report. J Gerontol A Biol Sci Med Sci 64(2):155–156

    PubMed  Google Scholar 

  • Suominen H, Heikkinen E (1975) Enzyme activities in muscle and connective tissue of M. Vastus lateralis in habitually training and sedentary 33 to 70-year-old men. Eur J Appl Physiol Occup Physiol 34(5):249–254

    Article  PubMed  CAS  Google Scholar 

  • Tanskanen M, Peuralinna T, Polvikoski T, Notkola IL, Sulkava R, Hardy J, Singleton A, Kiuru-Enari S, Paetau A, Tienari PJ, Myllykangas L (2008) Senile systemic amyloidosis affects 25% of the very aged and associates with genetic variation in alpha2-macroglobulin and tau: a population-based autopsy study. Ann Med 40(3):232–239

    Article  PubMed  CAS  Google Scholar 

  • Tiainen K, Sipilä S, Alén M, Heikkinen E, Kaprio J, Koskenvuo M, Tolvanen A, Pajala S, Rantanen T (2005) Shared genetic and environmental effects on strength and power in older female twins. Med Sci Sport Exerc 37(1):72–78

    Article  Google Scholar 

  • Tiainen K, Perola M, Kovanen V, Sipilä S, Tuononen K, Rikalainen K, Kauppinen M, Widen E, Kaprio J, Rantanen T, Kujala UM (2008) Genetics of maximal walking speed and skeletal muscle characteristics in older women. Twin Res Hum Genet 11(3):321–334

    Article  PubMed  Google Scholar 

  • Tyynismaa H, Suomalainen A (2009) Mouse models of mitochondrial DNA defects and their relevance for human disease. EMBO Rep 10(2):137–143

    Article  PubMed  CAS  Google Scholar 

  • Vahtola E, Louhelainen M, Forstén H, Merasto S, Raivio J, Kaheinen P, Kytö V, Tikkanen I, Levijoki J, Mervaala E (2010) Sirtuin1–p53, forkhead box O3a, p38 and post-infarct cardiac remodeling in the spontaneously diabetic Goto-Kakizaki rat. Cardiovasc Diabetol 9:5

    Article  PubMed  Google Scholar 

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Acknowledgments

This publication was prepared under the auspices of the Finnish Gerontological Society (Societas Gerontologica Fennica, SGF). TES is the president and SS a board member of SGF.

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Correspondence to Timo E. Strandberg.

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Strandberg, T.E., Sipilä, S. Biogerontology in Finland. Biogerontology 12, 71–75 (2011). https://doi.org/10.1007/s10522-010-9313-4

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  • DOI: https://doi.org/10.1007/s10522-010-9313-4

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