Abstract
Authors provide results of their review of research in the field of biogerontology. Despite the fact that the term “biogerontology” is not commonly used in Czech scientific practice, there have been many research efforts in this field. Up to present, the Czech research teams have focused on the theoretical and biological models of ageing, its immunological aspects, the risk factors of unsuccessfull human ageing, and also metabolic and nutritional factors. Many research teams are dealing with the mechanisms of the neurodegeneration. The authors conclude that better coordination and systematic funding of research in gerontology is needed because of the actual demographic challenges.
Similar content being viewed by others
References
Arking DE, Krebsova A, Macek M Sr, Macek M Jr, Arking A, Mian IS, Fried L, Hamosh A, Dey S, McIntosh I, Dietz HC (2002) Association of human aging with a functional variant of klotho. Proc Natl Acad Sci USA 99(2):856–861
Bartek J, Hodný Z, Lukás J (2009) Cytokine loops driving senescence. Nat Cell Biol 10:8
Buckiova D, Popelar J, Syka J (2007) Aging cochleas in the F344 rat: morphological and functional changes. Exp Gerontol 42(7):629–638
Burianova J, Ouda L, Profant O, Syka J (2009) Age-related changes in GAD levels in the central auditory system of the rat. Exp Gerontol 44(3):161–169
Cejková J, Vejrazka M, Pláteník J, Stípek S (2004) Age-related changes in superoxide dismutase, glutathione peroxidase, catalase and xanthine oxidoreductase/xanthine oxidase activities in the rabbit cornea. Exp Gerontol 39(10):1537–1543
Chvátal A, Anderová M, Neprasová H et al (2008) Pathological potential of astroglia. Physiol Res 57: S101–S110
Deyl Z, Juricová M, Rosmus J, Adam M (1971) Aging of the connective tissue:collagen cross linking in animals of different species and equal age. Exp Gerontol 6(3):227–233
Doubal S (1982) Theory of reliability, biological systems and aging. Mech Ageing Dev 18:349–353
Doubal S, Klemera P (1990) Influence of aging rate changes on mortality curves. Mech Ageing Dev 54:75–85
Doubal S, Klemera P (1999a) The effect of antioxidants and dietary restriction on mortality curves. AGE 22:101–105
Doubal S, Klemera P (1999b) Methods of verification of aging theories. Ces Fyziologie 48(4):171–178
Doubal S, Klemera P (2002) Visco-elastic response of human skin and aging. J Am Aging Assoc 3(25):115–117
Doubal S, Klemera P, Filipová M, Dolejš J (1997) Teoretická gerontologie. Karolinum, Praha
Druga R (2008) Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat. Exp Gerontol 43:8
Dufek M, Hamanová M, Lokaj, Goldemund D, Rektorová I, Michálková Z, Sheardová K, Rektor I (2009) Serum inflammatory biomarkers in Parkinson’s disease. Parkinsonism Rel Disord 15(4):318–320
Filip S, Mokrý J (2005) Stem cells, their plasticity, regeneration and ageing. Ces Ger Rev 3(4):51–56
Hamerníková M, Koubská O, Zácková P, Doubal S (2008) Effect of the long-term application of melatonin on the state and vitality of rats. Folia Pharmaceutica, Universitatis Carolinae, p 37
Hanus M, Matousková M, Starka L, Hill L (2006) Hormonal homeostasis in a group of 216 aging Czech males and correlation with responses to a questionnaire of the University of St Louis. Aging Male 9(2):103–110
Holmerová I (2010) History of Czech Gerontology. CGGS, Praha
Hort J, Laczo J, Vyhnalek M (2008) Spatial navigation deficit in amnestic Mild cognitive impairment. Proc Natl Acad Sci USA 104(10):4042–4047
Janderová-Rossmeislová L, Nováková Z, Vlasáková J, Philimonenko J, Hozák P, Hodný Z (2007) PML protein association with specific nucleolar structures differs in normal, tumor and senescent human cells. J Struct Biol 159(1):6–70
Juraskova B, Andrys I, Holmerova I, Solichova D, Hrnciarikova D, Vankova H, Vasatko T, Krejsek J (2009) Transforming growth factor beta and soluble endoglin in the healthy senior and in Alzheimer’s disease patients. J Nutr Health Aging. doi:10.1007/s12603-009-0146-2
Kalová E, Vlcek K, Jarolímová E et al (2005) Allothetic orientation and sequential ordering of places is impaired in early stages of Alzheimer’s disease: corresponding results in real space tests and computer tests. Behav Brain Res 159(2):175–186
Kalvach Z, Zadak Z, Jirak R (2004) Geriatrie a gerontologie [Geriatrics and gerontology] Prague. Grada Publishing, Czech Republic
Klemera P, Doubal S (2000) Gompertz—a program for evaluation and comparison of survival curves. AGE 23:129–130
Klemera P, Doubal S (2005) A new approach to the concept and computation of biological age. Mech Ageing Dev 127(3):240–248
Krejsek J, Kudlová M, Koláčková M (2005) Imunitní systém a stárnutí (The Immune System and Ageing). Ces Ger Rev 3(4):36–42
Kristofiková Z, Benesová O, Tejkalová H (1993) Comparison of the effects of aging in vivo and of oxygen free radicals in vitro on high-affinity choline uptake and hemicholinium-3 binding in the rat brain. Arch Gerontol Geriatr 17(3):179–188
Kristofiková Z, Klaschka J, Tejkalová H (1995a) Effect of aging on lipid peroxide levels induced by L-glutamic acid and estimated by means of a thiobarbituric acid test in rat brain tissue. Exp Gerontol 30(6):645–657
Kristofiková Z, Fales E, Majer E, Klaschka J (1995b) 3H-hemicholinium-3 binding sites in postmortem brains of human patients with Alzheimer’s disease and multi-infarct dementia. Exp Gerontol 30(2):125–136
Kristofiková Z, Majer E, Fales E, Pĕkný I, Klaschka J (1998) Effects of aging and dementia on the levels of thiobarbituric-acid-reactive products stimulated by L-glutamic acid in human autopsy and biopsy brain tissue. Dement Geriatr Cogn Disord 9(1):6–12
Kristofiková Z, Bocková M, Hegnerová K, Bartos A, Klaschka J, Ricný J, Ripová D, Homola J (2009) Enhanced levels of mitochondrial enzyme 17beta-hydroxysteroid dehydrogenase type 10 in patients with Alzheimer disease and multiple sclerosis. Mol Biosyst 5(10):1174–1179
Kubesová H, Holík J, Bogrová I, Syslová D (2001) Pain in elderly patients and aspects of its therapy. Cas Lek Ces 140(10):291–294
Laczó J, Vlcek K, Vyhnálek M, Vajnerová O, Ort M, Holmerová I, Tolar M, Andel R, Bojar M, Hort J (2009) Spatial navigation testing discriminates two types of amnestic mild cognitive impairment. Behav Brain Res 202(2):252–259
Mazurova Y (2006) Apoptosis of subependymal cells as the reaction to the neurodegeneration in rat striatum. Univerzita Komenského v Bratislave: Morfológia v súčasnosti 222–227
Motlík J, Hruska-Plochan M, Lacková M, Vodicka P, Usvald D, Pavlok A, Marsala M (2008) Miniature pig model of neurodegenerative diseases. In: Abstracts from 6th international symposium on experimental and clinical neurobiology
Ouda L, Druga R, Syka J (2008) Changes in parvalbumin immunoreactivity with aging in the central auditory system of the rat. Exp Gerontol 43(8):782–789
Pokorný J (2009) CNS its structure and function. Martin, Osveta
Procházková D, Wilhelmová N (2007) Leaf senescence and activities of the antioxidant enzymes. Biologia Plantarum 51(3):41–46
Rektorova I (2008) Demence u Parkinsonovy nemoci (Dementia in Parkinsons′s Disease). Ceská Geriatrická Revue 6(4):171–176
Rofina JE, Singh K, Skoumalová-Veselá A, van Ederen AM, van Asten AJAM, Wilhelm J, Gruys E (2004) Histochemical accumulation of oxidative damage products is associated with Alzheimer-like pathology in the canine. Amyloid 11:90–100
Rokyta R (2004) Patofyziologie bolesti ve vyšším věku a ve stáří (Patophysiology of pain in older and old age). Ces Ger Rev 2(1):22–26
Rokyta R (2005) Volně radikálová teorie stárnutí (Ageing and the free radicals theory). Ces Ger Rev 3(1):27–33
Rusina R, Ridzoň P, Kulišt’ák P, Keller O, Bartoš A, Buncová M et al (2010) Relationship between ALS and the degree of cognitive impairment, markers of neurodegeneration and predictors for poor outcome. A prospective study. Eur J Neurol 17:23–30
Sajko S, Kubínová L, Kreft M, Dahmane R, Wernink A, Erzen I (2002) Improving methodological strategies for satellite cells counting in human muscle during ageing. Image Anal Stereol 21(1):7–12
Skoumalová A, Rofina J, Schwippelová Z, Gruys E, Wilhelm J (2003) The role of free radicals in canine counterpart of senile dementia of the Alzheimer type. Exp Gerontol 38:711–719
Skrha J (2009) Effect of caloric restriction on oxidative markers. Adv Clin Chem 47:224–242
Srbová M, Wilhelmová N, Wilhelm J (2001) Molekulární mechanismy stárnutí živočichů a rostlin vycházejících z oxidačního stresu (Molecular mechanisms of ageing based on the oxidative stress both of animals and plants). Biologické listy 66(3):203–220
Stárka L (2003) Stárnoucí muž z pohledu endokrinologa (Ageing male from the point of view of endocrinologist). Ces Ger Rev 1(3):6–12
Strunecká A (2004) Synergistic effects of aluminium and fluoride on the pathophysiological hallmarks of Alzheimer′s dementia. Physiol Res 53(4):34–35
Topinková E (2008) Aging, disability and frailty. Ann Nutr Metab 52(Suppl 1):6–11
Acknowledgments
This publication was supported by the institutional research plan MSM 0021620843 “The Anthropology of Communication and Human Adaptation” of the Faculty of Humanities, Charles University in Prague.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Holmerová, I., Vanková, H. & Jurasková, B. Biogerontology in the Czech Republic. Biogerontology 12, 31–35 (2011). https://doi.org/10.1007/s10522-010-9300-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10522-010-9300-9