Peptide bioregulation of aging: results and prospects

Abstract

The review comprises the results of author’s long-term investigation in the mechanisms of aging and a role of peptide bioregulators in prevention of age-related pathology. A number of small peptides have been isolated from different organs and tissues and their analogues (di-, tri-, tetrapeptides) were synthesized from the amino acids. It was shown that long-term treatment with some peptide preparations increased mean life span by 20–40%, slow down the age-related changes in the biomarkers of aging and suppressed development of spontaneous and induced by chemical or radiation carcinogens tumorigenesis in rodents. Possible mechanisms of the biological effects of small peptides are discussed in the paper. The results of clinical applications of peptide preparation during the period of 6–12 years are presented as well.

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Acknowledgments

The author expresses his sincere gratitude to our colleagues from the St. Petersburg Institute of Bioregulation and Gerontology and from another research institutes over Russia, Ukraine and Belorussia as well as foreign colleagues Professors J. Atzpodien (Germany), K. R. Boheler (USA), C. Franceschi (Italy), E. Lakatta (USA), T. A. Lezhava (Georgia), J. Martinez (France), M. Passeri (Italy), Y. Touitou (France), A. I. Yashin (USA), I. Zusman (Israel) for their significant contribution into our research work.

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Correspondence to Vladimir N. Anisimov.

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Anisimov, V.N., Khavinson, V.K. Peptide bioregulation of aging: results and prospects. Biogerontology 11, 139–149 (2010). https://doi.org/10.1007/s10522-009-9249-8

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Keywords

  • Small peptides
  • Pineal gland
  • Thymus
  • Life span extension
  • Tumors
  • Rodents