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Changes of brain activity in the aged SAMP mouse

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Abstract

This study investigates characteristics of aging in the central nervous system of the senescence accelerated prone mice (SAMP8). We examined 3 and 10-months old senescence-accelerated-prone mice (SAMP8) for functional and molecular changes in their brains, specifically in the hippocampus and somatosensory cortex. There was no statistically significant increase in the apoptosis indicators as revealed by Western Blotting for BAD and TUNEL experiments. However, the functional magnetic resonance imaging showed an increase in the area of BOLD images from the 3-month old to the 10-months old SAMP mice upon the application of tail stimulus. These results demonstrated a lack of neuronal deaths but an increase in the activated brain area with age.

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Authors and Affiliations

  1. Department of Neurology, The First Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China

    Lihong Zhang

  2. Department of Anatomy, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong S.A.R., China

    Qi Li, Lucille T. Wolff, Aiqun Zhang & David T. Yew

  3. Department of Diagnostic Radiology and Organ Imaging, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China

    Gregory E. Antonio & David K. W. Yeung

  4. Institute of Geriatrics and Gerontology, Chinese PLA General Hospital, Beijing , 100853, China

    Aiqun Zhang

  5. Department of Anatomy, Capital University of Medical Sciences, Beijing , 100054, China

    Yan Wu

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  1. Lihong Zhang
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  2. Qi Li
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  3. Lucille T. Wolff
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  5. David K. W. Yeung
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  8. David T. Yew
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Correspondence to David T. Yew.

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Zhang, L., Li, Q., Wolff, L.T. et al. Changes of brain activity in the aged SAMP mouse. Biogerontology 8, 81–88 (2007). https://doi.org/10.1007/s10522-006-9035-9

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  • DOI: https://doi.org/10.1007/s10522-006-9035-9

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