, Volume 6, Issue 1, pp 71–75 | Cite as

Exercise and hormesis: oxidative stress-related adaptation for successful aging

  • Zsolt RadakEmail author
  • Hae Young Chung
  • Sataro Goto


The hormesis theory purports that biological systems respond with a bell-shaped curve to exposure to chemicals, toxins, and radiation. Here we extend the hormesis theory to include reactive oxygen species (ROS). We further suggest that the beneficial effects of regular exercise are partly based on the ROS generating capability of exercise, which is in the stimulation range of ROS production. Therefore, we suggest that exercise-induced ROS production plays a role in the induction of antioxidants, DNA repair and protein degrading enzymes, resulting in decreases in the incidence of oxidative stress-related diseases and retardation of the aging process.


anti-oxidants DNA repair exercise hormesis oxygen reactive species (ROS) 


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Copyright information

© Springer 2005

Authors and Affiliations

  1. 1.Exercise Physiology Laboratory, School of Sport ScienceSemmelweis UniversityBudapestHungary
  2. 2.Department of PharmacologyPusan National UniversityKorea
  3. 3.Department of Biochemistry, Faculty of Pharmaceutical SciencesToho UniversityFunabashiJapan

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