Abstract
Maternal smoking during pregnancy (MSDP) has been robustly associated with externalizing problems and their developmental precursors in offspring in studies using behavioral teratologic designs (Wakschlag et al., Am J Public Health 92(6):966–974, 2002; Espy et al., Dev Psychol 47(1):153–169, 2011). In contrast, the use of behavior genetic approaches has shown that the effects commonly attributed to MSDP can be explained by family-level variables (D’Onofrio et al., Dev Psychopathol 20(01):139–164, 2008). Reconciling these conflicting findings requires integration of these study designs. We utilize longitudinal data on a preschool proband and his/her sibling from the Midwest Infant Development Study-Preschool (MIDS-P) to test for teratologic and family level effects of MSDP. We find considerable variation in prenatal smoking patterns both within and across pregnancies within families, indicating that binary smoking measures are not sufficiently capturing exposure. Structural equation models indicate that both conduct disorder and oppositional defiant disorder symptoms showed unique effects of MSDP over and above family level effects. Blending high quality exposure measurement with a within-family design suggests that it is premature to foreclose the possibility of a teratologic effect of MSDP on externalizing problems. Implications and recommendations for future studies are discussed.
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Acknowledgments
We gratefully acknowledge the members of the Developmental Cognitive Neuroscience Laboratory for assistance with data collection and coding and the families who made this research possible. Ryne Estabrook, Carrie Clark, Brian Mustanski, Edwin Cook, Kimberly Espy and Lauren Wakschlag were all supported by R01 DA023653 (PIs: Wakschlag and Espy). Suena Massey was supported by K23 DA037913 (PI: Massey), Kimberly Espy was also supported by R01 DA014661 (PI: Espy) and Lauren Wakschlag was also supported by the Walden & Jean Young Shaw Foundation.
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Ryne Estabrook, Suena H. Massey, Caron A. C. Clark, James L. Burns, Brian S. Mustanski, Edwin H. Cook, T. Caitlin O’Brien, Beth Makowski, Kimberly A. Espy and Lauren S. Wakschlag declare that they have no conflicts of interest.
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This research was completed with appropriate review by the institutional review boards of the authors’ universities. All data collection and data manipulation was compliant with rules regarding ethical treatment of human subjects and informed consent.
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Appendix
Appendix
Appendix 1
See Table 5.
Appendix 2: Power simulation
To test our assertion that our longitudinal assessment increases power over a single assessment of SDP, we created a small Monte Carlo simulation. Data were generated using either a single continuous SDP indicator or three indicators correlated 0.8. We varied the sample size (values of 250, 500, 750 and 1000) and the size of the individual level effect from our model in Fig. 2 (Bdirect of 0.1, 0.2, 0.3 and 0.4). The direct effect was held constant at 0.1, while the within-family correlations of both SDP and externalizing were held constant at 0.5. These values are reasonably close to those found in our empirical data, but with a much wider range of sample sizes to inform future studies. We created 250 datasets for each condition, generated an empirical power estimate as the proportion of studies within a cell that find the effect, and presented all results in Fig. 4.
We found three occasion exposure models with power of .8 have their power reduced to .602 when reduced to a single measure. Three occasions with power of .9 have power of .735 with a single measure.
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Estabrook, R., Massey, S.H., Clark, C.A.C. et al. Separating Family-Level and Direct Exposure Effects of Smoking During Pregnancy on Offspring Externalizing Symptoms: Bridging the Behavior Genetic and Behavior Teratologic Divide. Behav Genet 46, 389–402 (2016). https://doi.org/10.1007/s10519-015-9762-2
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DOI: https://doi.org/10.1007/s10519-015-9762-2