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Genetic and Environmental Variation in Lung Function Drives Subsequent Variation in Aging of Fluid Intelligence

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Abstract

Longitudinal studies document an association of pulmonary function with cognitive function in middle-aged and older adults. Previous analyses have identified a genetic contribution to the relationship between pulmonary function with fluid intelligence. The goal of the current analysis was to apply the biometric dual change score model to consider the possibility of temporal dynamics underlying the genetic covariance between aging trajectories for pulmonary function and fluid intelligence. Longitudinal data from the Swedish Adoption/Twin Study of Aging were available from 808 twins ranging in age from 50 to 88 years at the first wave. Participants completed up to six assessments covering a 19-year period. Measures at each assessment included spatial and speed factors and pulmonary function. Model-fitting indicated that genetic variance for FEV1 was a leading indicator of variation in age changes for spatial and speed factors. Thus, these data indicate a genetic component to the directional relationship from decreased pulmonary function to decreased function of fluid intelligence.

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Acknowledgments

The Swedish Adoption/Twin Study of Aging (SATSA) is supported by NIA (AG04563, AG10175), The MacArthur Foundation Research Network on Successful Aging, the Swedish Council for Social Research (97:0147:1B), and the Swedish Research Council.

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Authors and Affiliations

  1. Department of Psychology, Indiana University Southeast, New Albany, IN, USA

    Deborah Finkel

  2. Department of Psychology, University of California, Riverside, Riverside, CA, USA

    Chandra A. Reynolds

  3. Departments of Psychology and Internal Medicine, Institute for Behavioral Medicine Research, Ohio State University, Columbus, OH, USA

    Charles F. Emery

  4. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden

    Nancy L. Pedersen

  5. Department of Psychology, University of Southern California, Los Angeles, CA, USA

    Nancy L. Pedersen

Authors
  1. Deborah Finkel
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  2. Chandra A. Reynolds
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  3. Charles F. Emery
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  4. Nancy L. Pedersen
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Correspondence to Deborah Finkel.

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Edited by Kristen Jacobson.

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Finkel, D., Reynolds, C.A., Emery, C.F. et al. Genetic and Environmental Variation in Lung Function Drives Subsequent Variation in Aging of Fluid Intelligence. Behav Genet 43, 274–285 (2013). https://doi.org/10.1007/s10519-013-9600-3

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  • DOI: https://doi.org/10.1007/s10519-013-9600-3

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