Behavior Genetics

, Volume 43, Issue 2, pp 151–160 | Cite as

Competitive Ability in Male House Mice (Mus musculus): Genetic Influences

  • Christopher B. CunninghamEmail author
  • James S. Ruff
  • Kevin Chase
  • Wayne K. Potts
  • David R. Carrier
Original Research


Conspecifics of many animal species physically compete to gain reproductive resources and thus fitness. Despite the importance of competitive ability across the animal kingdom, specific traits that influence or underpin competitive ability are poorly characterized. Here, we investigate whether there are genetic influences on competitive ability within male house mice. Additionally, we examined if litter demographics (litter size and litter sex ratio) influence competitive ability. We phenotyped two generations for a male’s ability to possess a reproductive resource––a prime nesting site––using semi-natural enclosures with mixed sex groupings. We used the “Animal Model” coupled with an extensive pedigree to estimate several genetic parameters. Competitive ability was found to be highly heritable, but only displayed a moderate genetic correlation to body mass. Interestingly, litter sex ratio had a weak negative influence on competitive ability. Litter size had no significant influence on competitive ability. Our study also highlights how much remains unknown about the proximal causes of competitive ability.


Heritability Genetic correlation Life-history evolution Male–male competition Sexual selection 



We would like to thank Fred Adler, Elizabeth Cashdan, Terry Dial, Gordon Lark, Allen Moore, Nadja Schilling, and Jon Seger for insightful discussions. We would also like to thank Terry Dial and Daryl McLaren who helped with data collection and Linda Morrison who maintained the mouse population’s pedigree. This work was primarily funded through the University of Utah Funding Incentive Seed Grant Program to DR Carrier. Additional funding was provided through NSF grants to DR Carrier (IOS 08-17782) and WK Potts (DEB 09-18969) and an NIH grant to WK Potts (RO1-GM039578). CB Cunningham and JS Ruff were supported by NSF GK-12 Educational Outreach Fellowships (DGE 08-41233).


  1. Barkley M, Goldman B (1977) A quantitative study of serum testosterone, sex accessory organ growth, and the development of intermale aggression in the mouse. Horm Behav 8:208–218PubMedCrossRefGoogle Scholar
  2. Barrette C (1987) Dominance cannot be inherited. Trends Ecol Evol 2:251PubMedCrossRefGoogle Scholar
  3. Barrette C (1993) The “inheritance of dominance”, or of an aptitude to dominate? Anim Behav 46:591–593CrossRefGoogle Scholar
  4. Benton D, Dalrymple-Alford J, Brain F (1980) Comparisons of measures of dominance in the laboratory mouse. Anim Behav 28:1274–1279CrossRefGoogle Scholar
  5. Berry RJ (1991) House mouse Mus domesticus. In: Corbet GB, Harris S (eds) Handbook of British mammals. Blackwell, Oxford, pp 239–247Google Scholar
  6. Blanchard RJ, Flores T, Magee W, Weiss S, Blanchard DC (1992) Pregrouping aggression and defense scores influences alcohol consumption for dominant and subordinate rats in visible burrow systems. Aggress Behav 18:459–467CrossRefGoogle Scholar
  7. Briffa M, Sneddon LU (2007) Physiological constraints on contest behaviour. Funct Ecol 21:627–637CrossRefGoogle Scholar
  8. Bult A, Lynch CB (1997) Nesting and fitness: lifetime reproductive success in house mice bidirectionally selected for thermoregulatory nest-building behavior. Behav Genet 27:231–240PubMedCrossRefGoogle Scholar
  9. Carrier DR (2007) The short legs of great apes: evidence for aggressive behavior in Australopiths. Evolution 61:596–605PubMedCrossRefGoogle Scholar
  10. Carroll LS, Meagher S, Morrison L, Penn D, Potts WK (2004) Fitness effects of a selfish gene are revealed in an ecological context. Evolution 58:1318–1328PubMedGoogle Scholar
  11. Craig JV, Ortman LL, Guhl AM (1965) Genetic selection for social dominance ability in chickens. Anim Behav 13:114–131CrossRefGoogle Scholar
  12. Crawley JN (2007) What’s wrong with my mouse?. Behavioral phenotyping of transgenic and knockout mice, WileyCrossRefGoogle Scholar
  13. Crowcroft P (1955) Territoriality in wild mice, Mus musculus L. J Mammal 36:299–301CrossRefGoogle Scholar
  14. Cunningham CB, Ruff JS, Chase K, Potts WK, Carrier DR (2012a) Competitve ability in male house mice (Mus musculus): the influence of body mass under differing levels of social competitionGoogle Scholar
  15. Cunningham CB, Ruff JS, Edmunds T, Chase K, Carrier DR (2012b) Competitive ability and aggression are different phenomena in male house miceGoogle Scholar
  16. Darwin C (1871) The descent of man and selection in relation to sex. Murray, LondonCrossRefGoogle Scholar
  17. De Fries J, McClearn G (1970) Social dominance and Darwinian fitness in the laboratory mouse. Am Nat 104:408–411CrossRefGoogle Scholar
  18. Desjardins C, Maruniak JA, Bronson FH (1973) Social rank in house mice: differentiation reveled by ultraviolet visualization of urinary marking patterns. Science 182:939–941PubMedCrossRefGoogle Scholar
  19. Dewsbury DA (1982) Dominance rank, copulatory behavior, and differential reproduction. Q Rev Biol 57:135–159PubMedCrossRefGoogle Scholar
  20. Dewsbury DA (1990) Fathers and sons: genetic factors and social dominance in deer mice, Peromyscus maniculatus. Anim Behav 39:284–289CrossRefGoogle Scholar
  21. Dietz DM, LaPlant Q, Watts EL, Hodes GE, Russo SJ, Feng J, Oosting RS, Vialou V, Nestler E (2011) Paternal transmission of stress-induced pathologies. Biol Psychiatry 70:408–414PubMedCrossRefGoogle Scholar
  22. Drickamer LC (2001) Urine marking and social dominance in male house mice (Mus musculus domesticus). Behav Process 53:113–120CrossRefGoogle Scholar
  23. Ellis L (1995) Dominance and reproductive success among nonhuman animals: a cross-species comparison. Ethol Sociobiol 16:257–333CrossRefGoogle Scholar
  24. Ely DL, Henry JP (1978) Neuroendocrine response patterns in dominant and subordinate mice. Horm Behav 10:156–169PubMedCrossRefGoogle Scholar
  25. Emlen D (2008) The evolution of animal weapons. Annu Rev Ecol Evol Syst 39:387–413CrossRefGoogle Scholar
  26. Falconer D, Mackay T (1996) Introduction to quantitative genetics. Longman, NYGoogle Scholar
  27. Francis RC (1984) The effects of bidirectional selection for social dominance on agonistic behavior and sex ratios in the paradise fish (Macropodus opercularis). Behaviour 90:25–45CrossRefGoogle Scholar
  28. Fuxjager MJ, Forbes-Lorman RM, Coss DJ, Auger CJ, Auger AP, Marler CA (2010) Winning territorial disputes selectively enhances androgen sensitivity in neural pathways related to motivation and social aggression. Proc Natl Acad Sci USA 107:12393–12398PubMedCrossRefGoogle Scholar
  29. Garratt M, Stockley P, Armstrong SD, Beynon RJ, Hurst J (2011) The scent of senescence: sexual signalling and female preference in house mice. J Evol Biol 24:2398–2409PubMedCrossRefGoogle Scholar
  30. Gerlach G (1990) Dispersal mechanisms in a captive wild house mouse population (Mus musculus Rutty). Biol J Linn Soc 41:271–277CrossRefGoogle Scholar
  31. Gerlach G (1996) Emigration mechanisms in feral house mice––a laboratory investigation of the influence of social structure, population density, and aggression. Behav Ecol Sociobiol 39:159–170CrossRefGoogle Scholar
  32. Gomez MD, Priotto J, Provensal MC, Steinmann A, Castillo E, Polop JJ (2008) A population study of house mice (Mus musculus) inhabiting different habitats in an Argentine urban area. Int Biodeterior Biodegradation 62:270–273CrossRefGoogle Scholar
  33. Hadfield J (2010) MCMC methods for multi-response generalized linear mixed models: the MCMglmm R package. J Stat Softw 33:1–22Google Scholar
  34. Hand J (1986) Resolution of social conflicts: dominance, egalitarianism, spheres of dominance, and game theory. Q Rev Biol 61:201–220CrossRefGoogle Scholar
  35. Hayashi S (1993) Development and diversity of social structure in male mice. J Ethol 11:77–82CrossRefGoogle Scholar
  36. Hurst J (1987) Behavioural variation in wild house mice Mus domesticus Rutty: a quantitative assessment of female social organization. Anim Behav 35:1846–1857CrossRefGoogle Scholar
  37. Huyghe K, Vanhooydonck B, Scheers H, Molica-Borja M, Van Damme R (2005) Morphology performance and fighting capacity in male lizards, Gallotia galloti. Funct Ecol 19:800–807CrossRefGoogle Scholar
  38. Ilmonen P, Penn DJ, Damjanovich K, Clarke J, Lamborn D, Morrison L, Ghotbi L, Potts WK (2008) Experimental infection magnifies inbreeding depression in house mice. J Evol Biol 21:834–841PubMedCrossRefGoogle Scholar
  39. Kaufmann J (1983) On the definitions and functions of dominance and territoriality. Biol Rev 58:1–20CrossRefGoogle Scholar
  40. Knudsen B (1962) Growth and reproduction of house mice at three different temperatures. Oikos 13:1–14CrossRefGoogle Scholar
  41. Konig B, Riester J, Markl H (1988) Maternal care in house mice (Mus musculus): II. The energy cost of lactation as a function of litter size. J Zool 216:195–210CrossRefGoogle Scholar
  42. Krackow S (1993) The effect of weaning weight on offspring fitness in wild house mice (Mus musculus domesticus): a preliminary study. Ethology 95:76–82CrossRefGoogle Scholar
  43. Krackow S, Matuschak B (1991) Mate choice for non-siblings in wild house mice: evidence from a choice test and a reproductive test. Ethology 88:99–108CrossRefGoogle Scholar
  44. Kuse A, De Fries J (1976) Social dominance and Darwinian fitness in laboratory mice: an alternative test. Behav Biol 16:113–116PubMedCrossRefGoogle Scholar
  45. Lailvaux SP, Herrel A, VanHooydonck B, Meyers JJ, Irschick DJ (2004) Performance capacity, fighting tactics and the evolution of life-stage male morphs in the green anole lizard (Anolis carolinensis). Proc Ro Soc Lond 271:2501–2508CrossRefGoogle Scholar
  46. Lappin AK, Husak JF (2005) Weapon performance, not size, determines mating success and potential reproductive output in the collared lizard (Crotaphytus collaris). Am Nat 166:426–436PubMedCrossRefGoogle Scholar
  47. Lidicker WZ (1976) Social behaviour and density regulation in house mice living in large enclosures. J Anim Ecol 45:677–697CrossRefGoogle Scholar
  48. Louch CD, Higginbotham M (1967) The relation between social rank and plasma corticosterone levels in mice. Gen Comp Endocrinol 8:441–444PubMedCrossRefGoogle Scholar
  49. Manning C, Wakeland E, Dewsbury DA, Potts WK (1995) Communal nesting and communal nursing in housemice, Mus musculus domesticus. Anim Behav 50:741–751CrossRefGoogle Scholar
  50. McGlothlin JW, Moore AJ, Wolf JB, Brodie ED III (2010) Interacting phenotypes and the evolutionary process. III. Social evolution. Evolution 64:2558–2574PubMedCrossRefGoogle Scholar
  51. Meagher S, Penn D, Potts WK (2000) Male–male competition magnifies inbreeding depression in wild house mice. Proc Natl Acad Sci USA 97:3324–3329PubMedCrossRefGoogle Scholar
  52. Miller RA, Harper JM, Dysko RC, Durkee SJ, Austad SN (2002) Longer life spans and delayed maturation in wild-derived mice. Exp Biol Med 227:500–508Google Scholar
  53. Moore AJ (1990) The inheritance of social dominance, mating behaviour and attractiveness to mates in male Nauphoeta cinerea. Anim Behav 39:388–397CrossRefGoogle Scholar
  54. Moore A (1993) Towards an evolutionary view of social dominance. Anim Behav 46:594–596CrossRefGoogle Scholar
  55. Moore AJ, Brodie ED III, Wolff JB (1997a) Interacting phenotypes and the evolutionary process: I. Direct and indirect genetic effects of social interactions. Evolution 51:1352–1362CrossRefGoogle Scholar
  56. Moore PJ, Reagan-Wallin NL, Haynes KF, Moore AJ (1997b) Odour conveys status on cockroaches. Nature 389:25CrossRefGoogle Scholar
  57. Moore AJ, Haynes KF, Preziosi RF, Moore PJ (2002) The evolution of interacting phenotypes: genetics and evolution of social dominance. Am Nat 160:S186–S197PubMedCrossRefGoogle Scholar
  58. Nol E, Cheng K, Nichols C (1996) Heritability and phenotypic correlations of behaviour and dominance rank of Japanese quail. Anim Behav 52:813–820CrossRefGoogle Scholar
  59. Oakeshott JG (1974) Social dominance, aggressiveness, and mating success among male house mice (Mus musculus). Oecologia 15:143–158CrossRefGoogle Scholar
  60. Oyegbile TO, Marler CA (2005) Winning fights elevates testosterone levels in California mice and enhances future ability to win fights. Horm Behav 48:259–267PubMedCrossRefGoogle Scholar
  61. Pasi B, Carrier DR (2003) Functional trade-offs in the limbs of dogs selected for running vs. fighting. J Evol Biol 16:324–332PubMedCrossRefGoogle Scholar
  62. Phelps SM, Lydon JP, O’Malley BW, Crews D (1998) Regulation of male sexual behavior by progesterone receptor, sexual experience, and androgen. Horm Behav 34:294–302PubMedCrossRefGoogle Scholar
  63. Potts WK, Manning C, Wakeland E (1991) Mating patterns in semi-natural populations of mice influenced by MHC genotype. Nature 352:619–621PubMedCrossRefGoogle Scholar
  64. R-Development-Core-Team (2011) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna. ISBN 3-900051-07-0Google Scholar
  65. Rolland C, MacDonald D, de Fraipont M, Berdoy M (2003) Free female choice in house mice: leaving best for last. Behaviour 140:1371–1388CrossRefGoogle Scholar
  66. Ruff JS, Nelson AC, Kubinak JL, Potts WK (2012) MHC signaling during social communication. Adv Exp Med Biol 738:290–313. doi: 10.1007/978-1-4614-1680-7_17 PubMedCrossRefGoogle Scholar
  67. Rusu AS, Krackow S, Jedelsky PL, Stopka P, Konig B (2008) A qualitative investigation of major urinary proteins in relation to the onset of aggressive behavior and dispersive motivation in male wild house mice (Mus musculus domesticus). J Ethol 26:127–135CrossRefGoogle Scholar
  68. Satori C, Mantovani R (2012) Indirect genetic effects and the genetic bases of social dominance: evidence from cattle. Heredity 110:1–7. doi: 10.1038/hdy.2012.56 Google Scholar
  69. Sutherland D, Spencer P, Singleton G, Taylor A (2005) Kin interactions and changing social structure during a population outbreak of feral house mice. Mol Ecol 14:2803–2814PubMedCrossRefGoogle Scholar
  70. Vom Saal F, Bronson FH (1980) Sexual characteristics of adult female mice are correlated with their blood testosterone levels during prenatal development. Science 208:597–599PubMedCrossRefGoogle Scholar
  71. Vom Saal F, Grant WM, McMullen CW, Laves KS (1983) High fetal estrogen concentrations: correlations with increased adult sexual activity and decreased aggression in male mice. Science 220:1306–1309PubMedCrossRefGoogle Scholar
  72. Wilson A, Reale D, Clements M, Morrissey M, Postma E, Walling C, Kruuk L, Nussey D (2009a) An ecologist’s guide to the animal model. J Anim Ecol 79:13–26CrossRefGoogle Scholar
  73. Wilson B, Nicholas F, James J, Thomson P (2009b) Comparison of genetic parameters obtained from an ordinal canine hip phenotype data set by linear or ordinal analysis. Proc Assoc Adv Anim Breed Genet 18:450–453Google Scholar
  74. Wolff JO (1985) Mating behavior and female choice: the relation to social structure in wild caught house mice (Mus musculus) housed in semi-natural environment. J Zool Lond 207:43–51CrossRefGoogle Scholar
  75. Wright S (1921) Coefficients of inbreeding and relationship. Am Nat 56:330–338CrossRefGoogle Scholar
  76. Zala S, Potts WK, Penn D (2008) Exposing males to female scent increases the cost of controlling Salmonella infection in wild house mice. Behav Ecol Sociobiol 62:895–900CrossRefGoogle Scholar
  77. Zielinski W, Vom Saal F, Vandenbergh J (1992) The effect of intrauterine position on the survival, reproduction, and home range size of female house mice (Mus musculus). Behav Ecol Sociobiol 30:185–191CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Christopher B. Cunningham
    • 1
    • 2
    Email author
  • James S. Ruff
    • 1
  • Kevin Chase
    • 1
  • Wayne K. Potts
    • 1
  • David R. Carrier
    • 1
  1. 1.Department of BiologyUniversity of UtahSalt Lake CityUSA
  2. 2.Department of GeneticsUniversity of GeorgiaAthensUSA

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