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The G619A Aa-nat Gene Polymorphism does not Contribute to Sleep Time Variation in the Brazilian Population

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Abstract

Genes involved in melatonin synthesis, such as Aa-nat, may be important for our understanding of diurnal preference and circadian rhythm disturbances in humans. In Japan, Hohjoh et al. reported increased allelic frequencies of the 619A allele of the G619A Aa-nat gene polymorphism in a sample of Delayed Sleep Phase Syndrome (DSPS) patients. The present study sought to analyze G619A polymorphism frequency in a Brazilian sample, including DSPS patients. We found almost no allelic variation for G619A polymorphism in our sample, except for two heterozygous samples out of 551. Our results leave open the question of whether there would be an association if there were some genetic variation in our population. It is important to analyze different ethnic groups in order to validate the effect of G619A polymorphism on sleep timing.

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Acknowledgements

We are thankful to FAPESP (grant #98/14303-3) and AFIP for financial support. We would also like to thank the technical assistance of the Institute of Pharmacology of UNIFESP in DNA sequencing.

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Authors and Affiliations

  1. Department of Psychobiology/Sleep Institute, Universidade Federal de São Paulo, Rua Napoleão de Barros 925, Sao Paulo, SP, 04024-002, Brazil

    Danyella Silva Pereira, Mario Pedrazzoli, Bruna Del Vechio Koike, Ana Amélia Benedito-Silva, Alberto Remesar Lopez & Sergio Tufik

  2. Department of Physiology, Universidade Federal do Paraná, Curitiba, PR, Brazil

    Fernando Mazzili Louzada

Authors
  1. Danyella Silva Pereira
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  2. Mario Pedrazzoli
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  3. Bruna Del Vechio Koike
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  4. Fernando Mazzili Louzada
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  5. Ana Amélia Benedito-Silva
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  6. Alberto Remesar Lopez
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  7. Sergio Tufik
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Corresponding author

Correspondence to Mario Pedrazzoli.

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Edited by John K Hewitt

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Pereira, D.S., Pedrazzoli, M., Koike, B.D.V. et al. The G619A Aa-nat Gene Polymorphism does not Contribute to Sleep Time Variation in the Brazilian Population. Behav Genet 37, 637–638 (2007). https://doi.org/10.1007/s10519-007-9155-2

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  • DOI: https://doi.org/10.1007/s10519-007-9155-2

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