Behavior Genetics

, Volume 36, Issue 4, pp 567–576 | Cite as

The Implications of Simultaneous Smoking Initiation for Inferences about the Genetics of Smoking Behavior from Twin Data

  • Michele L. Pergadia
  • Andrew C. Heath
  • Arpana Agrawal
  • Kathleen K. Bucholz
  • Nicholas G. Martin
  • Pamela A. F. Madden
Article

Abstract

We examined early social influences across stages of smoking within the context of a twin study using an environmental exposure specific to smoking: whether twins started smoking at the same time (“simultaneous smoking initiation”: SSI). We expected that SSI would be a good index of shared social influences on smoking initiation. Rates of SSI were indeed significantly higher in MZ twins and in twins who shared peers and classes, as well as in male twins. With the exception of regular smoking in females, we found no significant difference in estimates of genetic and environmental parameters between SSI and non-SSI pairs for any of the smoking measures that we examined (DSM-IV and Fagerstrom HSI measures of nicotine dependence; DSM-IV nicotine withdrawal; heavy smoking; and in males, regular smoking). For regular smoking in females, allowing for additional shared environmental influences associated with SSI only modestly reduced our estimates of additive genetic variance (56% vs. 68%). These results indicate the important social influences that may occur for smoking initiation do not appear to seriously bias estimates of genetic effects on later stages of smoking.

Key words:

Environmental influences genetic influences simultaneous smoking initiation twin data 

References

  1. American Psychiatric Association (1994). Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition). Washington, DC, American Psychiatric AssociationGoogle Scholar
  2. Bucholz K. K., Cadoret R., Cloninger C. R., et al. (1994). A new semi-structured psychiatric interview for use in genetic linkage studies: A report of the reliability of the SSAGA. J. Studies Alcohol, 55:149–158Google Scholar
  3. Center for Disease Control and Prevention (1998). Selected cigarettes smoking initiation and quitting behaviors among high school students—United States, 1997. Morb. Mortal. Wkly., 47 (19):386–389Google Scholar
  4. Center for Disease Control and Prevention (2002). Annual smoking-attributable mortality, years of potential life lost, and economic costs- United States, 1995–1999. Morb. Mortal. Wkly., 51 (14):300–302Google Scholar
  5. Center for Disease Control and Prevention (2004). Cigarette use among high school students- United States, 1991–2003. Morb. Mortal. Wkly., 53 (23):499–502Google Scholar
  6. Center for Disease Control and Prevention (2005). Annual smoking-attributable mortality, years of potential life lost, and economic costs- United States, 1997–2001. Morb. Mortal. Wkly., 54 (25):625–628Google Scholar
  7. Cleveland H. H., Wiebe R. P., Rowe D. C. (2005). Sources of exposure to smoking and drinking friends among adolescents: a behavioral-genetic evaluation. J. Genetic Psychol., 166(2):153–169Google Scholar
  8. Cottler L. B., Robins L. N., Grant B. F., et al. (1991). The CIDI-core substance abuse and dependence questions: Cross-cultural and nosological issues. The WHO/ADAMHA field trial. Br. J. Psychiatry, 159:653–658PubMedCrossRefGoogle Scholar
  9. Eaves, L. J., Last, K. A., Young, P. A. Martin, N. G. (1978). Model-fitting approaches to the analysis of human behavior. Heredity 41: 249–320PubMedCrossRefGoogle Scholar
  10. Heath A. C., Cates R., Martin N. G., Meyer J., Hewitt J. K., Neale M. C., Eaves L. J. (1993). Genetic contribution to risk of smoking initiation: Comparison across birth cohorts and across cultures. J. Subst. Abuse 5: 221–246CrossRefPubMedGoogle Scholar
  11. Heath A. C., Howells W., Kirk K. M., Madden P. A. F., Bucholz K. K., Nelson E. C., Slutske W. S., Statham D. J., Martin N. G. (2001). Predictors of non-response to a questionnaire survey of a volunteer twin panel: findings from the Australian 1989 twin cohort. Twin Res. 4(2): 73–80CrossRefPubMedGoogle Scholar
  12. Heath A. C., Madden P. A. F. (1995). Genetic influences on smoking behaviors. In: Turner J.R., Cardon L.R., Hewitt J.K. (eds). Behavior Genetic Approaches in Behavioral Medicine. Plenum, New York, pp. 45–66Google Scholar
  13. Heath A. H., Martin N. G., Lynskey M. T., Todorov A. A., Madden P. A. F. (2002). Estimating two-stage models for genetic influences on alcohol, tobacco or drug use initiation and dependence vulnerability in twin and family data. Twin Res. 5 (2): 113–124CrossRefPubMedGoogle Scholar
  14. Heatherton T. F., Kozlowski L. T., Frecker R. C., Fagerstrom K. O. (1991). The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br. J. Addict. 86(9):1119–1127CrossRefPubMedGoogle Scholar
  15. Heatherton T. F., Kozlowski L. T., Frecker R. C., Rickert W., Robinson J. (1989). Measuring the heaviness of smoking: using self-reported time to the first cigarette of the day and number of cigarettes smoked per day. Br. J. Addict. 84(7):791–799CrossRefPubMedGoogle Scholar
  16. Kendler K. S., Gardner C. O. Jr. (1998). Twin studies of adult psychiatric and substance dependence disorders: are they biased by differences in the environmental experiences of monozygotic and dizygotic twins in childhood and adolescence? Psychol. Med. 28(3): 625–633CrossRefPubMedGoogle Scholar
  17. Kendler K. S., Neale M. C., Sullivan P., Corey L. A., Gardner C. O., Prescott C. A. (1999). A population-based twin study in women of smoking initiation and nicotine dependence. Psychol. Med. 29: 299–308CrossRefPubMedGoogle Scholar
  18. Knopik V. S., Heath A. C., Madden P. A. F., Bucholz K. K., Slutske W. S., Nelson E. C., Statham D., Whitfield J. B., Martin N. G. (2004). Genetic effects on alcohol dependence risk: re-evaluating the importance of psychiatric and other heritable risk factors. Psychol. Med. 34(8): 1519–1530CrossRefPubMedGoogle Scholar
  19. Koopmans J. R., Slutske W. S., Heath A. C., Neale M. C., Boomsma D. I. (1999). The genetics of smoking initiation and quantity smoked in Dutch adolescent and young adult twins. Behav. Genet. 29(6): 383–393CrossRefPubMedGoogle Scholar
  20. Lessov C. N., Martin N. G., Statham D. J., Todorov A. A., Slutske W. S., Bucholz K. K., Heath A. C., Madden P. A. F. (2004). Defining nicotine dependence for genetic research: evidence from Australian twins. Psychol. Med. 34: 865–879CrossRefPubMedGoogle Scholar
  21. Li M. D., Cheng R., Ma J. Z., Swan G. E. (2003). A meta-analysis of estimated genetic and environmental effects on smoking behavior in male and female twins. Addiction 98: 23–31CrossRefPubMedGoogle Scholar
  22. Madden P. A. F., Heath A. C., Pedersen N. L., Kaprio J. K., Koskenvuo M. J., Martin N. G. (1999). The genetics of smoking persistence in men and women: a multicultural study. Behav. Genet. 29: 421–429CrossRefGoogle Scholar
  23. Madden P. A. F., Pedersen N. L., Kaprio J., Koskenvou M. J., Martin N. G. (2004). The epidemiology and genetics of smoking initiation and persistence: crosscultural comparisons of twin study results. Twin Res. 7 (1): 82–97CrossRefPubMedGoogle Scholar
  24. Maes H. H., Sullivan P. F., Bulik C. M., Neale M. C., Prescott C. A., Eaves L. J., Kendler K. S. (2004). A twin study of genetic and environmental influences on tobacco initiation, regular tobacco use and nicotine dependence. Psychol. Med. 34: 1251–1261CrossRefPubMedGoogle Scholar
  25. Merikangas K. R., Risch N. (2003). Genomic priorities and public health. Science 302: 599–601CrossRefPubMedGoogle Scholar
  26. Neale M. C., Boker S. M., Xie G., Maes H. H. (2002). MX: Statisical Modeling. Department of Psychiatry, Medical College of Virginia, Richmond, VA 6th EditionGoogle Scholar
  27. Peto R., Darby S., Deo H., Silcocks P., Whitley E., Doll R. (2000). Smoking, smoking cessation, and lung cancer in the UK since 1950: combination of national statistics with two case–control studies. Br. Med. J. 321: 323–329CrossRefGoogle Scholar
  28. Pomerleau O. F., Collins A. C., Shiffman S., Pomerleau C. S. (1993). Why some people smoke and others do not: New perspectives. J. Consult. Clin. Psychol. 61: 723–732CrossRefPubMedGoogle Scholar
  29. SAS Institute Inc. (1999). SAS® Procedures Guide, Version 8. Cary, NC: SAS Institute IncGoogle Scholar
  30. Simons-Morton B. G. (2002). Prospective analysis of peer and parent influences on smoking initiation among early adolescents. Prev. Sci. 3 (4): 275–283CrossRefPubMedGoogle Scholar
  31. Slomkowski C., Rende R., Novak S., Lloyd-Richardson E., Niaura R. (2005). Sibling effects on smoking in adolescence: evidence for social influence from a genetically informative design. Addiction 100(4): 430–438CrossRefPubMedGoogle Scholar
  32. StataCorp (2003). Stata statistical software, Release 8.0. College Station, TX: Stata CorporationGoogle Scholar
  33. Thomson C. C., Fisher L. B., Winickoff J. P., Colditz G. A., Camargo C. A., Jr., King C., III, Frazier A. L. (2004). State tobacco excise taxes and adolescent smoking behaviors in the United States. J. Public Health Manage. Practice 10 (6): 490–496Google Scholar
  34. Vink J. M., Willemsen G., Boomsma D. I. (2003). The association of current smoking behavior with the smoking behavior of parents, siblings, friends and spouses. Addiction 98(7): 923–931CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Michele L. Pergadia
    • 1
    • 3
  • Andrew C. Heath
    • 1
  • Arpana Agrawal
    • 1
  • Kathleen K. Bucholz
    • 1
  • Nicholas G. Martin
    • 2
  • Pamela A. F. Madden
    • 1
  1. 1.Department of PsychiatryWashington University School of MedicineSt. LouisUSA
  2. 2.Queensland Institute of Medical ResearchBrisbaneAustralia
  3. 3.Department of PsychiatryWashington University School of MedicineSt. LouisUSA

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