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Experimental Approaches to Scar Modeling through Mechanical Skin Damage and Chemical Burn in Sprague Dawley Rats

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Bulletin of Experimental Biology and Medicine Aims and scope

Creating of a scar model in laboratory animals is the most acceptable option for the preclinical search of scar treatment. However, due to high skin regeneration rate in laboratory rodents, creating an optimal animal model of scar formation is a challenge. Here we describe five methods for modeling a scar tissue in rats that we have tested. These methods allowed achieving different histopathological features and different stages of skin scar formation.

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Authors and Affiliations

  1. Branch of Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Moscow region, Russia

    Yu. A. Palikova, V. A. Palikov, V. A. Kazakov, N. A. Borozdina, S. G. Semushina & I. A. Dyachenko

  2. Pushchino Branch of Russian Biotechnological University (ROSBIOTECH), Pushchino, Moscow Region, Russia

    V. A. Palikov, N. A. Borozdina, K. V. Khmara & I. A. Dyachenko

Authors
  1. Yu. A. Palikova
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  2. V. A. Palikov
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  3. V. A. Kazakov
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  4. N. A. Borozdina
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  5. K. V. Khmara
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  6. S. G. Semushina
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  7. I. A. Dyachenko
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Corresponding author

Correspondence to N. A. Borozdina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 176, No. 11, pp. 664-668, November, 2023

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Palikova, Y.A., Palikov, V.A., Kazakov, V.A. et al. Experimental Approaches to Scar Modeling through Mechanical Skin Damage and Chemical Burn in Sprague Dawley Rats. Bull Exp Biol Med 176, 640–644 (2024). https://doi.org/10.1007/s10517-024-06084-1

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  • DOI: https://doi.org/10.1007/s10517-024-06084-1

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